Murray J L, Bernfield M
Department of Pediatrics, Stanford University School of Medicine, CA 94305.
N Engl J Med. 1988 Nov 24;319(21):1385-91. doi: 10.1056/NEJM198811243192105.
Black infants are born with low birth weights (less than 2500 g) and very low birth weights (less than 1500 g) at twice the rate of white infants. We investigated the effect of prenatal care delivered in a health maintenance organization on the birth weights of black and white infants at normal risk for low birth weight. Using birth certificates for all children born in 1978 in the California Kaiser-Permanente hospitals, we studied data on more than 31,000 black and white newborns whose mothers' ages and levels of education were comparable. The data show that black mothers used prenatal care less extensively and had a higher incidence of infants with low birth weights (8.4 vs. 3.6 percent) and very low birth weights (2.0 vs. 0.7 percent) than white mothers. The difference in the use of prenatal care, however, accounted for less than 15 percent of the difference in the incidence of low birth weight. The rates of low birth weight, very low birth weight, and preterm birth (less than 260 days' gestation) decreased with increasing levels of prenatal care for both blacks and whites. However, increasing levels of care were associated with a greater reduction among black infants than among white infants in low birth weight, very low birth weight, and low birth weight at term (greater than or equal to 260 days' gestation). When we compared mothers who received adequate care with those who received inadequate care, the relative risk of giving birth to a very-low-birth-weight infant was reduced 3.6-fold (95 percent confidence interval, 2.0 to 6.6) for black mothers and 2.1-fold (confidence interval, 1.3 to 3.4) for white mothers; the relative risk of giving birth to a low-birth-weight infant at term was reduced 3.4-fold (95 percent confidence interval, 2.2 to 5.4) for black mothers and 1.6-fold (confidence interval, 1.1 to 2.3) for white mothers. We conclude that even in a population of women at low risk for giving birth to low-birth-weight infants, prenatal care is more beneficial for blacks than for whites.
黑人婴儿出生时低体重(低于2500克)和极低体重(低于1500克)的发生率是白人婴儿的两倍。我们调查了健康维护组织提供的产前护理对低体重正常风险的黑人和白人婴儿出生体重的影响。利用加利福尼亚州凯撒-永久医疗集团医院1978年出生的所有儿童的出生证明,我们研究了31000多名黑人和白人新生儿的数据,这些新生儿母亲的年龄和教育水平具有可比性。数据显示,与白人母亲相比,黑人母亲较少广泛使用产前护理,且低体重婴儿(8.4%对3.6%)和极低体重婴儿(2.0%对0.7%)的发生率更高。然而,产前护理使用情况的差异占低体重发生率差异的比例不到15%。黑人和白人的低体重、极低体重和早产(妊娠少于260天)发生率均随着产前护理水平的提高而降低。然而,护理水平的提高与黑人婴儿在低体重、极低体重和足月低体重(大于或等于260天妊娠)方面的降幅大于白人婴儿有关。当我们将接受充分护理的母亲与接受不充分护理的母亲进行比较时,黑人母亲生出极低体重婴儿的相对风险降低了3.6倍(95%置信区间,2.0至6.6),白人母亲降低了2.1倍(置信区间,1.3至3.4);黑人母亲生出足月低体重婴儿的相对风险降低了3.4倍(95%置信区间,2.2至5.4),白人母亲降低了1.6倍(置信区间,1.1至2.3)。我们得出结论,即使在生出低体重婴儿风险较低的女性群体中,产前护理对黑人的益处也大于白人。