噬菌体434 Cro/DNA复合物的结构。
Structure of a phage 434 Cro/DNA complex.
作者信息
Wolberger C, Dong Y C, Ptashne M, Harrison S C
机构信息
Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, Massachusetts.
出版信息
Nature. 1988 Oct 27;335(6193):789-95. doi: 10.1038/335789a0.
DOI:10.1038/335789a0
PMID:3185709
Abstract
Comparison of the crystal structure of a complex of the phage 434 Cro protein and a synthetic DNA operator with the complex of the same operator and the 434 repressor DNA-binding domain shows different DNA conformations in the two structures. Binding of the protein determines the precise conformation of the DNA in each case.
摘要
噬菌体434 Cro蛋白与合成DNA操纵基因复合物的晶体结构，同相同操纵基因与434阻遏蛋白DNA结合结构域复合物的晶体结构相比，显示出两种结构中DNA构象不同。在每种情况下，蛋白质的结合决定了DNA的精确构象。
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