噬菌体434阻遏物-操纵基因复合物的结构
Structure of the repressor-operator complex of bacteriophage 434.
作者信息
Anderson J E, Ptashne M, Harrison S C
出版信息
Nature. 1987;326(6116):846-52. doi: 10.1038/326846a0.
DOI:10.1038/326846a0
PMID:3553959
Abstract
The crystal structure of a specific complex between the DNA-binding domain of phage 434 repressor and a synthetic 434 operator DNA shows interactions that determine sequence-dependent affinity. The repressor recognizes its operators by its complementarity to a particular DNA conformation as well as by direct interaction with base pairs in the major groove.
摘要
噬菌体434阻遏物的DNA结合结构域与合成的434操纵基因DNA之间特定复合物的晶体结构显示了决定序列依赖性亲和力的相互作用。阻遏物通过与特定DNA构象的互补性以及与大沟中碱基对的直接相互作用来识别其操纵基因。
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