Zhang Shujun, Deng Mengxia, Wang Qian, Jiang Yanping, Xu Qian, Cao Lanqin
Department of Gynecology, Xiangya Hospital, Central South University, Changsha 410008, China.
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2019 Oct 28;44(10):1113-1119. doi: 10.11817/j.issn.1672-7347.2019.190153.
To investigate the correlation between soluble resistance-related calcium-binding protein (Sorcin) and chemoresistance or overall survival in patients with ovarian cancer. Methods: We detected the expression of Sorcin in 27 cases of chemoresistant ovarian cancer tissue and 37 cases of sensitive ovarian cancer tissue by immunohistochemistry, and analyzed the relationship between the protein and clinicopathological features or chemoresistance of ovarian cancer. Log-rank test was used to analyze the single factor impact on overall survival, Kaplan-Meier analysis was used to describe survival curve, and Cox proportional hazard model was used for multivariate analysis. Results: The immunoreactive scores for Sorcin in chemoresistant ovarian cancer tissues were higher than those in the sensitive ovarian cancer tissues (P<0.001). The levels of Sorcin inovarian cancer tissue did not show statistical significance with different ages, tumor stages, classifications, tissue types, degrees of ascites, omentums, and tumor metastases (P>0.05). The correlation between Sorcin and overall survival in resistant and sensitive ovarian cancer groups was not statistically significant (P>0.05), while there was a negative correlation between the expression of Sorcin and the overall survival of total cases (r=-0.326, P<0.05). Log-rank test showed that the drug resistance factor had a distinct impact on overall survival (P<0.001), and the Sorcin expression had an impact on overall survival (P<0.05). However, correlation between overall survival and the ages, ascites, omentum carcinoma, pathological types, pathological grade or FIGO staging was not significant (P>0.05). Cox proportional hazard model showed that drug resistance had a significant effect on overall survival (P<0.001), with a relative risk at 8.635, and the survival curve of the ovarian cancer sensitive group was obviously superior to that of ovarian cancer drug resistance group. Conclusion: Sorcin may be associated with drug resistance in ovarian cancer. The expression of Sorcin is correlated with the overall survival. The lower the Sorcin expression, the longer the survival time. Chemoresistance may act as an important independent prognostic factor for the poor prognosis for ovarian cancer.
探讨可溶性耐药相关钙结合蛋白（Sorcin）与卵巢癌患者化疗耐药及总生存期之间的相关性。方法：采用免疫组织化学法检测27例化疗耐药卵巢癌组织和37例化疗敏感卵巢癌组织中Sorcin的表达，并分析该蛋白与卵巢癌临床病理特征及化疗耐药之间的关系。采用对数秩检验分析单因素对总生存期的影响，用Kaplan-Meier分析描述生存曲线，用Cox比例风险模型进行多因素分析。结果：化疗耐药卵巢癌组织中Sorcin的免疫反应评分高于化疗敏感卵巢癌组织（P<0.001）。卵巢癌组织中Sorcin水平在不同年龄、肿瘤分期、分类、组织类型、腹水程度、大网膜及肿瘤转移情况方面差异无统计学意义（P>0.05）。Sorcin与耐药和敏感卵巢癌组总生存期之间的相关性无统计学意义（P>0.05），而Sorcin表达与全部病例总生存期呈负相关（r=-0.326，P<0.05）。对数秩检验显示耐药因素对总生存期有显著影响（P<0.001），Sorcin表达对总生存期有影响（P<0.05）。然而，总生存期与年龄、腹水、大网膜癌、病理类型、病理分级或国际妇产科联盟（FIGO）分期之间的相关性不显著（P>0.05）。Cox比例风险模型显示耐药对总生存期有显著影响（P<0.001），相对风险为8.635，卵巢癌敏感组的生存曲线明显优于卵巢癌耐药组。结论：Sorcin可能与卵巢癌耐药相关。Sorcin的表达与总生存期相关。Sorcin表达越低，生存时间越长。化疗耐药可能是卵巢癌预后不良的重要独立预后因素。
