Ghosh Sushmita, Sharma Arpana, Kumar R Suresh, Nasare Vilas
Department of Pathology and Cancer Screening, Chittaranjan National Cancer Institute, Kolkata, India.
Department of Life Science and Biotechnology, Jadavpur University, Kolkata, India.
Med Oncol. 2024 Dec 14;42(1):29. doi: 10.1007/s12032-024-02580-6.
Soluble resistant related calcium binding protein (Sorcin) plays an important role in tumor progression, angiogenesis, metastasis, and multidrug resistance. Differential expression of Sorcin across different cancers significantly correlates with key clinicopathological characteristics and survival outcomes, underscoring its potential as a prognostic marker. Its involvement in drug-resistant cancers further advert Sorcin as a promising therapeutic target. This review summarizes the mechanistic role of Sorcin in cancer, its contribution to drug resistance, clinical relevance, and the current and emerging therapeutic approaches aimed at translating Sorcin-targeted therapies into clinical practice.
可溶性耐药相关钙结合蛋白（Sorcin）在肿瘤进展、血管生成、转移和多药耐药中起重要作用。Sorcin在不同癌症中的差异表达与关键临床病理特征和生存结果显著相关，凸显了其作为预后标志物的潜力。它在耐药性癌症中的作用进一步表明Sorcin是一个有前景的治疗靶点。本综述总结了Sorcin在癌症中的作用机制、对耐药性的贡献、临床相关性，以及旨在将针对Sorcin的治疗方法转化为临床实践的现有和新兴治疗方法。
