多发性硬化症中血管密度和中心凹无血管区测量的评估：一项光学相干断层血管造影研究。
Assessments of vessel density and foveal avascular zone metrics in multiple sclerosis: an optical coherence tomography angiography study.
机构信息
Department of Ophthalmology, Mengucek Gazi Training and Research Hospital, Binali Yildirim University, Erzincan, Turkey.
Department of Neurology, Mengucek Gazi Training and Research Hospital, Binali Yildirim University, Erzincan, Turkey.
出版信息
Eye (Lond). 2020 Apr;34(4):771-778. doi: 10.1038/s41433-019-0746-y. Epub 2019 Dec 19.
BACKGROUND/OBJECTIVES: To investigate optical coherence tomography angiography (OCT-A) findings of foveal avascular zone (FAZ) metrics and macular & peripapillary vessel densities (VD) in subjects with multiple sclerosis (MS).
METHODS
The study design was prospective and cross-sectional. FAZ metrics and VDs of the superficial capillary plexus (SCP), deep capillary plexus (DCP), retinal peripapillary capillary plexus (RPCP) along with the structural OCT measurements were scanned by using the Nidek's RS-3000 Advance in MS patients and healthy controls. All subject also underwent an assessment of visual evoked potentials (VEPs). The relationships between the OCT-A parameters with other clinical findings were analysed.
RESULTS
Forty-seven MS patients (94 eyes) and 61 healthy volunteers (122 eyes) were included in this study. Thirty-five eyes of the MS patients had an ON history. The structural OCT measurements were significantly differed between the groups (P < 0.001). All FAZ metrics were inversely correlated with central foveal thickness (CFT) (P < 0.001). The FAZ area and perimeter were inversely correlated with the VD of both SCP and DCP (P < 0.05). The VDs of SCP and DCP were significantly differed between the study groups (P < 0.001). The VEP latency was inversely correlated with the retinal nerve fibre layer, macular and ganglion cell layer thicknesses, the VD of SCP, and the VD of the DCP (P < 0.001).
CONCLUSIONS
Based on OCT angiography, VDs of macular and peripapillary area may be useful in detecting damage from ON in patients with MS.
背景/目的：探讨多发性硬化症（MS）患者黄斑中心凹无血管区（FAZ）参数和黄斑及视盘周围血管密度（VD）的光相干断层扫描血管造影（OCT-A）结果。
方法
研究设计为前瞻性和横断面研究。使用 Nidek 的 RS-3000 Advance 在 MS 患者和健康对照组中扫描 FAZ 指标和浅层毛细血管丛（SCP）、深层毛细血管丛（DCP）、视网膜视盘周围毛细血管丛（RPCP）的 VD 以及结构 OCT 测量值。所有受试者还接受了视觉诱发电位（VEPs）评估。分析 OCT-A 参数与其他临床发现之间的关系。
结果
本研究纳入 47 例 MS 患者（94 只眼）和 61 名健康志愿者（122 只眼）。MS 患者中有 35 只眼有 ON 病史。两组间结构 OCT 测量值存在显著差异（P < 0.001）。所有 FAZ 指标均与中央视网膜厚度（CFT）呈负相关（P < 0.001）。FAZ 面积和周长与 SCP 和 DCP 的 VD 呈负相关（P < 0.05）。SCP 和 DCP 的 VD 在研究组之间存在显著差异（P < 0.001）。VEP 潜伏期与视网膜神经纤维层、黄斑和节细胞层厚度、SCP 的 VD 和 DCP 的 VD 呈负相关（P < 0.001）。
结论
基于 OCT 血管造影，黄斑和视盘周围区域的 VD 可能有助于检测 MS 患者 ON 引起的损伤。
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