Department of Ophthalmology, Faculty of Medicine, Erzincan Binali Yildirim University, Erzincan, Turkey.
Department of Ophthalmology, Health Science University Umraniye Training and Research Hospital, İstanbul, Turkey.
Curr Eye Res. 2021 Apr;46(4):579-584. doi: 10.1080/02713683.2020.1857779. Epub 2020 Dec 17.
: To evaluate the effects of low blood magnesium levels on the optic nerve, retina, and retinal vascular structure.: This observational and cross-sectional study was conducted between June 2019 and May 2020 with participants aged 20-39 years, who had a visual acuity of ≥20/20, the axial length of 22-24.5 mm, refractive defect spherical equivalent of ≤±3D, and intraocular pressure of ≤21 mm Hg. All participants had a complaint of twitching in their eyes. The participants with normal serum magnesium levels constituted the control group, and patients with hypomagnesemia constituted the patient group. Updated AngioScan software (Navis ver. 1.8.0.) of Nidek's RS-3000 Advance system was used to analyze the spectral domain-optical coherence tomography (SD-OCT) and optical coherence tomography-angiography (OCT-A) images.: A total of 100 right eyes of 100 individuals was included in the study. The mean retinal nerve fiber layer (RNFL) thickness was 108.52 ± 12.46 μm in the control group, and 97.3 ± 9.7 μm in the hypomagnesemia group ( < .001). In the control group, the global superficial capillary plexus (SCP) and deep capillary plexus (DCP) vessel densities (VDs) were 41.92 ± 2.29, and 37.54 ± 3.83, respectively. In the patient group, the global SCP and DCP VDs were 37.66 ± 3.14, and 32.95 ± 5.57, respectively. The SCP and DCP VD percentages were significantly lower in the patient group. The mean foveal avascular zone (FAZ) area, perimeter and circularity index (CI) were 0.32 ± 0.13 mm, 2.89 ± 0.59 mm, and 0.52 ± 0.09, respectively, for the control group and 0.38 ± 0.11 mm, 2.99 ± 0.64 mm, and 0.38 ± 0.1, respectively, for the patient group. The FAZ area and perimeter were significantly higher ( = .013 and = .001) and FAZ CI was significantly lower ( < .001) in the patients with hypomagnesemia.: Our study revealed that OCT and OCT-A measurements may be used in the determination of the optic nerve and retinal vascular structure changes in hypomagnesemia.
：评估低血镁水平对视神经、视网膜和视网膜血管结构的影响。：本观察性横断面研究于 2019 年 6 月至 2020 年 5 月进行，参与者年龄为 20-39 岁，视力≥20/20，眼轴长度为 22-24.5mm，屈光度等效球镜为≤±3D，眼压≤21mmHg。所有参与者均主诉眼睛抽搐。血清镁水平正常的参与者为对照组，低镁血症患者为患者组。使用 Nidek 的 RS-3000 高级系统的更新 AngioScan 软件（Navis ver.1.8.0.）分析谱域光相干断层扫描（SD-OCT）和光相干断层扫描血管造影（OCT-A）图像。：共纳入 100 名个体的 100 只右眼。对照组的视网膜神经纤维层（RNFL）平均厚度为 108.52±12.46μm，低镁血症组为 97.3±9.7μm（<.001）。在对照组中，全局浅层毛细血管丛（SCP）和深层毛细血管丛（DCP）血管密度（VD）分别为 41.92±2.29 和 37.54±3.83。在患者组中，全局 SCP 和 DCP VD 分别为 37.66±3.14 和 32.95±5.57。患者组的 SCP 和 DCP VD 百分比明显较低。对照组平均黄斑无血管区（FAZ）面积、周长和圆形指数（CI）分别为 0.32±0.13mm、2.89±0.59mm 和 0.52±0.09，患者组分别为 0.38±0.11mm、2.99±0.64mm 和 0.38±0.1mm。低镁血症患者的 FAZ 面积和周长明显更高（=0.013 和=0.001），FAZ CI 明显更低（<.001）。：我们的研究表明，OCT 和 OCT-A 测量可用于确定低镁血症患者视神经和视网膜血管结构的变化。
