《东地中海区域国家乳腺癌生存率：系统评价和荟萃分析》。
Survival Rate of Breast Cancer in Eastern Mediterranean Region Countries: A Systematic Review and Meta-Analysis.
机构信息
Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, IR.
GI Cancer Screening and Prevention Research Center, Guilan University of Medical Sciences, Rasht, IR.
出版信息
Ann Glob Health. 2019 Dec 4;85(1):138. doi: 10.5334/aogh.2521.
BACKGROUND
Breast cancer (BC) is one of the main problems of public health around the world. As a consequence, survival rates are one of the most salient indicators for assessing the quality of cancer control and treatment programs.
OBJECTIVES
The aim of this study is to evaluate the survival rate of breast cancer in the Eastern Mediterranean region at different periods of time.
METHODS
Medline/PubMed, ProQuest, Scopus, Embase, Web of Knowledge and Google Scholar databases until February 1, 2018. All observational studies (cross-sectional, case-control, and cohort) referring to the survival of breast cancer were included in the study. The heterogeneity and its value were examined by Cochran test and I statistics, respectively. Analysis of subgroups performed was based on geographical area and Human Development Index (HDI), using Stata 12 software.
FINDINGS
A total of 58 papers were analyzed. Based on a random effect model, the survival rates of breast cancer in different periods-1, 2, 3, 4, 5 and 10 years-were estimated at 93.9, 85, 79.8, 72.6, 69.2, 62.1 and 55.5 percent, respectively. The highest 10-year survival rate was in Iran (59.2%), and the lowest was observed in Bahrain (45%).
CONCLUSIONS
Evidence suggests that about half of the patients in this area would die before 10 years survival, which is different from more developed countries. Also, high survival rates are associated with high human development index, which can help health policy-makers to better predict the outcomes of patients.
背景
乳腺癌（BC）是全球公共卫生的主要问题之一。因此，生存率是评估癌症控制和治疗计划质量的最显著指标之一。
目的
本研究旨在评估不同时期地中海东部地区乳腺癌的生存率。
方法
检索 Medline/PubMed、ProQuest、Scopus、Embase、Web of Knowledge 和 Google Scholar 数据库，检索时间截至 2018 年 2 月 1 日。所有观察性研究（横断面、病例对照和队列研究）均纳入本研究。采用 Cochran 检验和 I 统计量评估异质性及其数值。使用 Stata 12 软件基于地理区域和人类发展指数（HDI）进行亚组分析。
发现
共分析了 58 篇论文。基于随机效应模型，估计不同时期（1、2、3、4、5 和 10 年）乳腺癌的生存率分别为 93.9%、85%、79.8%、72.6%、69.2%、62.1%和 55.5%。10 年生存率最高的是伊朗（59.2%），最低的是巴林（45%）。
结论
证据表明，该地区约有一半的患者在 10 年生存率之前会死亡，这与较发达国家不同。此外，高生存率与高人类发展指数相关，这可以帮助卫生政策制定者更好地预测患者的结局。
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