Derkaoui Touria, Bakkach Joaira, Mansouri Mohamed, Loudiyi Ali, Fihri Mohamed, Alaoui Fatima Zahra, Barakat Amina, El Yemlahi Bouchra, Bihri Hassan, Nourouti Naima Ghailani, Mechita Mohcine Bennani
Human Genomic Research Laboratory, Faculty of Sciences and Techniques of Tangier, University Abdelmalek Essaâdi, Tangier, Morocco.
Oncology Clinic Al Amal of Tangier, Tangier, Morocco.
BMC Womens Health. 2016 Oct 22;16(1):68. doi: 10.1186/s12905-016-0346-y.
Triple Negative Breast Cancer (TNBC) is defined by a lack of estrogen and progesterone receptor gene expression and by the absence of overexpression on HER2. It is associated to a poor prognosis. We propose to analyze the clinicopathologic and prognostic characteristics of this breast cancer subtype in a Mediterranean population originated or resident in the North of Morocco.
We conducted a retrospective study of 279 patients diagnosed with breast cancer between January 2010 and January 2015. Clinicopathologic and prognostic features have been analyzed. Disease-Free Survival (DFS) and Overall Survival (OS) have been estimated.
Of all cases, forty-nine (17.6 %) were identified as having triple negative breast cancer with a median age of 46 years. The average tumor size was 3.6 cm. The majority of patients have had invasive ductal carcinoma (91.8 %) and 40.4 % of them were grade III SBR. Nodal metastasis was detected in 38.9 % of the patients and vascular invasion was found in 36.6 % of them. About half of the patients had an early disease (53.1 %) and 46.9 % were diagnosed at an advanced stage. Patients with operable tumors (61.2 %) underwent primary surgery and adjuvant chemotherapy. Patients with no operable tumors (26.5 %) received neoadjuvant chemotherapy followed by surgery, and patients with metastatic disease (12.2 %) were treated by palliative chemotherapy. DFS and OS at 5 years were respectively 83.7 and 71.4 %. Among 49, twelve had recurrences, found either when diagnosing them or after a follow-up. Local relapse was 6.1 %. Lung and liver metastases accounted consecutively for 8.2 and 10.2 %. Bone metastases were found in 4.1 % and brain metastases in 2.1 % of the cases.
Our results are in accordance with literature data, particularly what concerning young age and poor prognosis among TNBC phenotype. Therefore, the identification of BRCA mutations in our population seems to be essential in order to better adapt management options for this aggressive form of breast cancer.
三阴性乳腺癌（TNBC）的定义是雌激素和孕激素受体基因表达缺失以及HER2无过表达。它与预后不良相关。我们建议分析摩洛哥北部本地或居住的地中海人群中这种乳腺癌亚型的临床病理和预后特征。
我们对2010年1月至2015年1月期间诊断为乳腺癌的279例患者进行了回顾性研究。分析了临床病理和预后特征。估计了无病生存期（DFS）和总生存期（OS）。
在所有病例中，49例（17.6%）被确定为三阴性乳腺癌，中位年龄为46岁。平均肿瘤大小为3.6厘米。大多数患者患有浸润性导管癌（91.8%），其中40.4%为SBR III级。38.9%的患者检测到淋巴结转移，36.6%的患者发现血管侵犯。约一半患者患有早期疾病（53.1%），46.9%在晚期被诊断。可手术肿瘤患者（61.2%）接受了一期手术和辅助化疗。不可手术肿瘤患者（26.5%）接受了新辅助化疗后再进行手术，转移性疾病患者（12.2%）接受了姑息化疗。5年时的DFS和OS分别为83.7%和71.4%。在49例患者中，12例复发，在诊断时或随访后发现。局部复发率为6.1%。肺和肝转移分别占8.2%和10.2%。骨转移在4.1%的病例中发现，脑转移在2.1%的病例中发现。
我们的结果与文献数据一致，特别是关于TNBC表型中年轻和预后不良的情况。因此，在我们的人群中鉴定BRCA突变似乎对于更好地调整这种侵袭性乳腺癌的治疗方案至关重要。
