Allsop D, Ikeda S, Bruce M, Glenner G G
Department of Pathology, University of California San Diego School of Medicine, La Jolla 92093.
Neurosci Lett. 1988 Oct 5;92(2):234-9. doi: 10.1016/0304-3940(88)90067-5.
In an immunohistochemical study of naturally-occurring and experimental scrapie in sheep, deposits of cerebrovascular amyloid were found to react with antibodies to hamster scrapie prion protein (PrP 27-30), but not with antibodies to the amyloid beta-protein of Alzheimer's disease. It is concluded that this vascular amyloid is formed from PrP and is therefore closely associated with scrapie infection. It is likely that this amyloid is formed from a host precursor protein as a specific pathological consequence of invasion by the scrapie agent.
在一项对绵羊自然发生的和实验性瘙痒病的免疫组织化学研究中，发现脑血管淀粉样沉积物与抗仓鼠瘙痒病朊病毒蛋白（PrP 27 - 30）的抗体发生反应，但不与阿尔茨海默病的β淀粉样蛋白抗体发生反应。得出的结论是，这种血管淀粉样物质由PrP形成，因此与瘙痒病感染密切相关。这种淀粉样物质很可能由宿主前体蛋白形成，是瘙痒病病原体入侵导致的一种特定病理结果。
