肾上腺素经不同给药途径对视网膜和脉络膜血流的影响。

Effects of epinephrine on retinal and choroidal blood flow through different routes of drug administration.

作者信息

Chiou G C, Girgis Z, Chiou F Y

机构信息

Department of Medical Pharmacology and Toxicology, Texas A & M University College of Medicine.

出版信息

Ophthalmic Res. 1988;20(5):293-7. doi: 10.1159/000266728.

DOI:10.1159/000266728

PMID:3186200

Abstract

Epinephrine (1, 3 and 10 micrograms/kg) was found to increase retinal and choroidal blood flow (22, 49 and 67%) when it was administered intravenously. The increase in retinal and choroidal blood flow coincided well with the increase in systemic blood pressure (44, 65 and 96%, respectively). When epinephrine (2%) was instilled to the eyes topically the retinal and choroidal blood flow decreased (15%) while systemic blood pressure remained unchanged. It is suggested that the decrease in retinal and choroidal blood flow by topical epinephrine could be the cause of epinephrine maculopathy reported previously. L-Timolol (0.25%, topically) did not affect retinal and choroidal blood flow significantly.

摘要

静脉注射肾上腺素（1、3和10微克/千克）时，视网膜和脉络膜血流量分别增加了22%、49%和67%。视网膜和脉络膜血流量的增加与全身血压的升高非常吻合（分别为44%、65%和96%）。当局部滴眼2%肾上腺素时，视网膜和脉络膜血流量减少了15%，而全身血压保持不变。提示局部应用肾上腺素导致视网膜和脉络膜血流量减少可能是先前报道的肾上腺素性黄斑病变的原因。局部应用0.25%L-噻吗洛尔对视网膜和脉络膜血流量无明显影响。