School of Chemistry and Life Science, Anshan Normal University, Anshan 114016, China.
School of Chemistry and Life Science, Anshan Normal University, Anshan 114016, China.
Spectrochim Acta A Mol Biomol Spectrosc. 2020 Mar 15;229:117951. doi: 10.1016/j.saa.2019.117951. Epub 2019 Dec 12.
A novel "off-on" colorimetric and fluorescent chemosensor N,N-bis(2-(rhodamine B amido)ethyl)pyridine-2,6-dicarboxamide (RhBEP) has been designed and synthesized, which can selectively detect the presence of Fe with about 75-fold enhancement in fluorescence emission intensity at 585 nm over various environmentally relevant metal cations such as Hg, Cu, Cr, Li, Na, K, Ag, Zn, Mg, Ca, Ba, Fe, Cd, Ni, Mn, Al, Bi and Au in PBS reaction media. The remarkable color change from UV-Vis titration experiments indicates that RhBEP can be used as a colorimetric chemosensor for Fe. The ultrasensitive detection limit for Fe in the fluorescence measurement is down to 2.0 × 10 mol·L. The recognition mechanism of RhBEP to Fe was analyzed by Job's plot and mass spectrometry analysis. In addition, the data from fluorescent cell imaging experiments confirmed that the chemosensor RhBEP has a promising application for the detection of Fe in biological systems.
一种新型的“开-关”比色和荧光化学传感器 N,N-双(2-(若丹明 B 酰胺基)乙基)吡啶-2,6-二甲酰胺（RhBEP）被设计和合成，它可以选择性地检测 Fe 的存在，在 PBS 反应介质中，相对于 Hg、Cu、Cr、Li、Na、K、Ag、Zn、Mg、Ca、Ba、Fe、Cd、Ni、Mn、Al、Bi 和 Au 等各种与环境相关的金属阳离子，荧光发射强度在 585nm 处约增强 75 倍。从紫外可见滴定实验中的显著颜色变化表明，RhBEP 可以用作 Fe 的比色化学传感器。荧光测量中对 Fe 的超灵敏检测限低至 2.0×10-7mol·L-1。通过 Job 图和质谱分析对 RhBEP 对 Fe 的识别机制进行了分析。此外，荧光细胞成像实验数据证实，化学传感器 RhBEP 在生物系统中检测 Fe 具有广阔的应用前景。
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