Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, Xi'an Jiaotong University College of Stomatology, Xi'an, Shaanxi, China.
Department of Orthodontics, Xi'an Jiaotong University College of Stomatology, Xi'an, Shaanxi, China.
Brain Behav. 2020 Jan;10(1):e01506. doi: 10.1002/brb3.1506. Epub 2019 Dec 20.
Orthodontic pain is the most common adverse side effect reported in the context of tooth movement. Given its central role in processing pain and negative emotion, the central nucleus of the amygdala (CeA) is thought to be a key site involved in orthodontic pain sensation.
In the present study, we therefore explored whether the CeA is involved in contributing to orthodontic pain in a rat model of tooth movement. For this study, we utilized adult male rats with bilateral sham or electrolytic CeA lesions (400 μA; 25 s), and then we analyzed face grooming behavior as a measure of pain sensation.
Through this approach, we found that there were time- and force-dependent factors influencing pain levels in these rats. We further found that bilateral CeA lesions markedly reduced tooth movement-induced orofacial pain and that unilateral CeA lesions did so to a lesser extent.
As such, these results suggest the CeA is a key area of orthodontic pain, with the results of this study highlighting potential avenues for achieving pain relief in those suffering from orthodontic pain.
正畸疼痛是牙齿移动过程中报告的最常见的不良反应。鉴于其在处理疼痛和负面情绪中的核心作用，杏仁中央核（CeA）被认为是参与正畸疼痛感知的关键部位。
在本研究中，我们因此探索了 CeA 是否参与了牙齿移动大鼠模型中正畸疼痛的产生。为此研究，我们使用了双侧假手术或电刺激 CeA 损伤（400μA；25s）的成年雄性大鼠，并分析了面部梳理行为作为疼痛感知的衡量标准。
通过这种方法，我们发现存在时间和力依赖性因素影响这些大鼠的疼痛水平。我们进一步发现双侧 CeA 损伤显著减轻了牙齿移动引起的口面部疼痛，而单侧 CeA 损伤的效果较小。
因此，这些结果表明 CeA 是正畸疼痛的关键区域，本研究的结果突出了在遭受正畸疼痛的人群中实现疼痛缓解的潜在途径。
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