Tsacopoulos M, Evêquoz-Mercier V, Perrottet P, Buchner E
Experimental Ophthalmology Laboratory, University of Geneva School of Medicine, Switzerland.
Proc Natl Acad Sci U S A. 1988 Nov;85(22):8727-31. doi: 10.1073/pnas.85.22.8727.
The retina of the honeybee drone is a nervous tissue in which glial cells and photoreceptor cells (sensory neurons) constitute two distinct metabolic compartments. Retinal slices incubated with 2-deoxy[3H]glucose convert this glucose analogue to 2-deoxy[3H]glucose 6-phosphate, but this conversion is made only in the glial cells. Hence, glycolysis occurs only in glial cells. In contrast, the neurons consume O2 and this consumption is sustained by the hydrolysis of glycogen, which is contained in large amounts in the glia. During photostimulation the increased oxidative metabolism of the neurons is sustained by a higher supply of carbohydrates from the glia. This clear case of metabolic interaction between neurons and glial cells supports Golgi's original hypothesis, proposed nearly 100 years ago, about the nutritive function of glial cells in the nervous system.
雄蜂的视网膜是一种神经组织，其中神经胶质细胞和光感受器细胞（感觉神经元）构成两个不同的代谢区室。用2-脱氧[³H]葡萄糖孵育的视网膜切片会将这种葡萄糖类似物转化为2-脱氧[³H]葡萄糖6-磷酸，但这种转化仅在神经胶质细胞中发生。因此，糖酵解仅发生在神经胶质细胞中。相反，神经元消耗氧气，这种消耗由神经胶质细胞中大量含有的糖原水解来维持。在光刺激期间，神经元增加的氧化代谢由神经胶质细胞提供的更多碳水化合物来维持。神经元与神经胶质细胞之间这种明显的代谢相互作用实例支持了近100年前高尔基提出的关于神经胶质细胞在神经系统中营养功能的原始假说。
