精神运动和认知改变的综合测量作为双相抑郁症的潜在标志
Combined Measures of Psychomotor and Cognitive Alterations as a Potential Hallmark for Bipolar Depression.
作者信息
Robin Alison, Sauvaget Anne, Deschamps Thibault, Bulteau Samuel, Thomas-Ollivier Véronique
机构信息
Laboratory "Movement, Interactions, Performance" (E.A. 4334), Faculty of Sport Sciences, University of Nantes, Nantes, France.
Addictology and Liaison Psychiatry Department, University Hospital Nantes, Nantes, France.
出版信息
Psychiatry Investig. 2019 Dec;16(12):954-957. doi: 10.30773/pi.2019.0116. Epub 2019 Dec 25.
OBJECTIVE
The current study aimed to examine whether specific features of psychomotor retardation (PMR) and cognitive functioning established different profiles in unipolar (UD) and bipolar depression (BD).
METHODS
Two groups of age-matched patients with UD (n=54) and BD (n=20) completed the Montgomery-Asberg Depression Rating Scale (MADRS/60), the Montreal Cognitive Assessment (MoCA/30), and the Salpêtrière Retardation Rating Scale (SRRS/60). We analyzed the group effect and then performed intra-group analyses.
RESULTS
The BD patients have higher SRRS score, and lower MoCA score than UD despite no difference on the level of depression between UD and BD. Our results show that PMR can be predicted by the level of depression in UD and by the cognitive alteration and onset of disease in BD.
CONCLUSION
PMR is a relevant marker of depression. Our results highlight the importance of concomitant evaluation of psychomotor and cognitive functions in the distinction of UD and BD symptoms.
目的
本研究旨在探讨精神运动迟缓（PMR）的特定特征和认知功能在单相抑郁（UD）和双相抑郁（BD）中是否建立了不同的特征。
方法
两组年龄匹配的UD患者（n = 54）和BD患者（n = 20）完成了蒙哥马利-阿斯伯格抑郁评定量表（MADRS/60）、蒙特利尔认知评估量表（MoCA/30）和萨尔佩特里埃迟缓评定量表（SRRS/60）。我们分析了组间效应，然后进行了组内分析。
结果
尽管UD和BD之间的抑郁水平没有差异，但BD患者的SRRS评分更高，MoCA评分更低。我们的结果表明，UD中的抑郁水平以及BD中的认知改变和疾病发作可以预测PMR。
结论
PMR是抑郁的一个相关标志物。我们的结果强调了在区分UD和BD症状时同时评估精神运动和认知功能的重要性。
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