Liu Penghong, Li Qi, Zhang Aixia, Liu Zhifen, Sun Ning, Yang Chunxia, Wang Yanfang, Zhang Kerang
Department of Psychiatry, First Hospital of Shanxi Medical University, Taiyuan 030001, People's Republic of China.
Department of Psychiatry, Shanxi Medical University, Taiyuan 030001, People's Republic of China.
Neuropsychiatr Dis Treat. 2020 Apr 28;16:1087-1093. doi: 10.2147/NDT.S249489. eCollection 2020.
To investigate the regional homogeneity (ReHo) between unipolar depression (UD) and bipolar disorder (BD), and to search for brain imaging markers for distinguishing UD and BD.
A total of 58 patients who met the diagnosis criteria of UD in DSM-Ⅳ, 40 patients who met the diagnosis criteria of BD in DSM-Ⅳ and 54 healthy controls (HC) completed the resting-state functional magnetic resonance (rs-fMRI) scans. The ReHo of the three groups was compared and Pearson correlation analysis was performed between the ReHo values and the clinical symptoms.
(1) Significant differences were found in the right hippocampus, right parahippocampal gyrus, right Inferior orbitofrontal gyrus, right superior temporal gyrus, right inferior temporal gyrus, and right middle occipital gyrus across the three groups. (2) Compared to HC, the ReHo in the right parahippocampal gyrus in UD significantly increased. (3) When compared to HC, the ReHo in the right hippocampus in BD significantly increased. The ReHo in the right middle occipital gyrus decreased. (4) Compared to UD, BD exhibited significantly decreased ReHo in the right inferior temporal gyrus. No correlations were observed between the scores of 24-item Hamilton Depression Rating Scale (HDMD-24), Hamilton Anxiety Scale (HAMA), Young Mania Rating Scale (YMRS), and the ReHo values of altered brain regions between BD and UD.
The results suggest that there was a considerable difference in the ReHo of brain among UD, BD, and HCs. ReHo in the right inferior temporal gyrus showed significant differences between BD and UD that might serve as neuroimaging markers to identify BD and UD.
探讨单相抑郁（UD）与双相情感障碍（BD）之间的局部一致性（ReHo），并寻找区分UD和BD的脑成像标志物。
58例符合DSM-Ⅳ中UD诊断标准的患者、40例符合DSM-Ⅳ中BD诊断标准的患者和54名健康对照者（HC）完成了静息态功能磁共振成像（rs-fMRI）扫描。比较三组的ReHo，并对ReHo值与临床症状进行Pearson相关性分析。
（1）三组在右侧海马、右侧海马旁回、右侧眶额下回、右侧颞上回、右侧颞下回和右侧枕中回存在显著差异。（2）与HC相比，UD患者右侧海马旁回的ReHo显著增加。（3）与HC相比，BD患者右侧海马的ReHo显著增加，右侧枕中回的ReHo降低。（4）与UD相比，BD患者右侧颞下回的ReHo显著降低。BD和UD之间，24项汉密尔顿抑郁量表（HDMD-24）、汉密尔顿焦虑量表（HAMA）、杨氏躁狂量表（YMRS）得分与脑区改变的ReHo值之间未观察到相关性。
结果表明，UD、BD和HC之间脑区的ReHo存在相当大的差异。BD和UD之间右侧颞下回的ReHo存在显著差异，可能作为识别BD和UD的神经影像学标志物。
