Hospital Universitari Vall d'Hebrón, Barcelona, Spain.
Hospital Universitari Vall d'Hebrón, Barcelona, Spain.
Enferm Infecc Microbiol Clin (Engl Ed). 2020 Oct;38(8):379-389. doi: 10.1016/j.eimc.2019.10.016. Epub 2019 Dec 24.
The immunosuppressive treatment that recipients receive from a solid organ transplantation hinders the defensive response to infection. Its transmission from the donor can cause dysfunction or loss of the graft and even death of the recipient if proper preventive measures are not established. This potential risk should be thoroughly evaluated to minimise the risk of infection transmission from donor to recipient, especially with organ transplantation from donors with infections, without increasing graft dysfunction and morbidity and mortality in the recipient. This document aims to review current knowledge about infection screening in potential donors and offer clinical and microbiological recommendations about the use of organs from donors with infection based on available scientific evidence.
受者接受的实体器官移植后的免疫抑制治疗会阻碍对感染的防御反应。如果没有建立适当的预防措施,供者的这种潜在风险可能会导致移植物功能障碍或丧失,甚至受者死亡。应彻底评估这种潜在风险,以尽量降低供者到受者的感染传播风险,特别是在从有感染的供者进行器官移植时,同时避免增加受者的移植物功能障碍和发病率及死亡率。本文件旨在回顾潜在供者感染筛查方面的现有知识,并根据现有科学证据提供有关使用感染供者器官的临床和微生物学建议。