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实体器官移植受者尿路感染的管理：西班牙传染病与临床微生物学会（SEIMC）移植受者感染研究小组（GESITRA）和西班牙传染病研究网络（REIPI）的共识声明

Management of urinary tract infection in solid organ transplant recipients: Consensus statement of the Group for the Study of Infection in Transplant Recipients (GESITRA) of the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC) and the Spanish Network for Research in Infectious Diseases (REIPI).

作者信息

Vidal Elisa, Cervera Carlos, Cordero Elisa, Armiñanzas Carlos, Carratalá Jordi, Cisneros José Miguel, Fariñas M Carmen, López-Medrano Francisco, Moreno Asunción, Muñoz Patricia, Origüen Julia, Sabé Núria, Valerio Maricela, Torre-Cisneros Julián

机构信息

Unidad Clínica de Gestión de Enfermedades Infecciosas, Instituto Maimónides de Investigación en Biomedicina de Córdoba, Hospital Universitario Reina Sofía, Universidad de Córdoba, Córdoba, Spain.

Servicio de Enfermedades Infecciosas, Hospital Clínic-Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Universidad de Barcelona, Barcelona, Spain.

出版信息

Enferm Infecc Microbiol Clin. 2015 Dec;33(10):679.e1-679.e21. doi: 10.1016/j.eimc.2015.03.024. Epub 2015 May 12.

DOI:10.1016/j.eimc.2015.03.024
PMID:25976754
Abstract

BACKGROUND

Urinary tract infections (UTIs) are one of the most common infections in solid organ transplant (SOT) recipients.

METHODS

Experienced SOT researchers and clinicians have developed and implemented this consensus document in support of the optimal management of these patients. A systematic review was conducted, and evidence levels based on the available literature are given for each recommendation. This article was written in accordance with international recommendations on consensus statements and the recommendations of the Appraisal of Guidelines for Research and Evaluation II (AGREE II).

RESULTS

Recommendations are provided on the management of asymptomatic bacteriuria, and prophylaxis and treatment of UTI in SOT recipients. The diagnostic-therapeutic management of recurrent UTI and the role of infection in kidney graft rejection or dysfunction are reviewed. Finally, recommendations on antimicrobials and immunosuppressant interactions are also included.

CONCLUSIONS

The latest scientific information on UTI in SOT is incorporated in this consensus document.

摘要

背景

尿路感染（UTIs）是实体器官移植（SOT）受者中最常见的感染之一。

方法

经验丰富的SOT研究人员和临床医生制定并实施了本共识文件，以支持对这些患者的最佳管理。进行了系统评价，并针对每项建议给出了基于现有文献的证据水平。本文是根据关于共识声明的国际建议以及《研究与评价指南评估II》（AGREE II）的建议撰写的。

结果

提供了关于无症状菌尿的管理以及SOT受者UTI的预防和治疗的建议。对复发性UTI的诊断-治疗管理以及感染在肾移植排斥或功能障碍中的作用进行了综述。最后，还包括了关于抗菌药物和免疫抑制剂相互作用的建议。

结论

本共识文件纳入了关于SOT中UTI的最新科学信息。

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