Miller J Z, Nance W E, Norton J A, Wolen R L, Griffith R S, Rose R J
JAMA. 1977 Jan 17;237(3):248-51.
Three different dosages of vitamin C, dependent on body weight, were administered to 44 school-aged monozygotic twins for five months using a double-blind, co-twin control study design. The mothers recorded daily observations of cold symptoms, and multiple biochemical, anthropometric, and psychological measurements were made at the beginning and end of the study. Paired comparisons showed no significant overall treatment effect on cold symptoms, but the response was not uniform in all sub-groups. Treated girls in the youngest two groups had significantly shorter and less severe illness episodes, and an effect on severity was also observed in the youngest group of boys. The seven treated twins in the latter group also grew an average of 1.3 cm more than their untreated co-twins during the five-minth period of the study.
根据体重，对44对学龄期同卵双胞胎给予三种不同剂量的维生素C，采用双盲、双胞胎对照研究设计，为期五个月。母亲们记录了感冒症状的每日观察情况，并且在研究开始和结束时进行了多项生化、人体测量和心理测量。配对比较显示，对感冒症状没有显著的总体治疗效果，但在所有亚组中的反应并不一致。最年幼的两组中接受治疗的女孩感冒发作时间明显更短、病情更轻，在最年幼的男孩组中也观察到了对病情严重程度的影响。在研究的五个月期间，后一组中接受治疗的七对双胞胎比未接受治疗的同卵双胞胎平均多长高了1.3厘米。
