Dryll A, Lansaman J, Peltier A P, Cazalis P, de Seze S, Bariéty J
Lab Invest. 1977 Jan;36(1):68-72.
An ultrastructural immunoperoxidase study of human synovial membrane biopsies performed in 16 patients with rheumatoid synovitis and in 14 control patients showed that: (1) plasma immunoglobulins have an intercellular distribution and seem to diffuse mainly by an intercellular rather than by a transcellular pathway; and (2) there is a difference in the distribution of plasma IgG and IgM. IgG was found in intravascular and extravascular spaces in all biopsies. IgM was found only in intravascular spaces in control biopsies, but in rheumatoid synovitis it was present in both intravascular and extravascular spaces. This difference in distribution may be due to increased vascular permeability in inflammatory synovitis.
对16例类风湿性滑膜炎患者和14例对照患者的人滑膜活检进行的超微结构免疫过氧化物酶研究表明：（1）血浆免疫球蛋白呈细胞间分布，似乎主要通过细胞间而非跨细胞途径扩散；（2）血浆IgG和IgM的分布存在差异。在所有活检中，IgG均存在于血管内和血管外间隙。在对照活检中，IgM仅存在于血管内间隙，但在类风湿性滑膜炎中，它存在于血管内和血管外间隙。这种分布差异可能是由于炎性滑膜炎中血管通透性增加所致。
