[Synovial vascularization and inflammation. II. Electron microscopy study of capillary permeability using immunoperoxidase].

The distribution of IgG and IgM into the normal and rheumatoid synovial membrane have been studied by the authors by means of immunoperoxidase electron-microscopy. Within the normal synovial while the IgG are diffusing out of the capillary the IgG are kept in the vascular lumen. Within the rheumatoid synovia IgG and IgM widely diffuse out of the microvasculature. This finding suggest that the rheumatoid inflammation is raising the permeability of synovial capillaries towards IgM molecules.