Totomoch-Serra Armando, Domínguez-Cruz Miriam Givisay, Muñoz María de Lourdes, García-Escalante María Guadalupe, Burgueño Juan, Díaz-Badillo Álvaro, Valadez-González Nina, Escalante Doris Pinto
Department of Genetics and Molecular Biology, Centro de Investigación y de Estudios Avanzados Del Instituto Politécnico Nacional, Mexico City, Mexico.
PhD Program in Medical Sciences, Universidad de La Frontera, Chile.
Data Brief. 2019 Nov 22;28:104866. doi: 10.1016/j.dib.2019.104866. eCollection 2020 Feb.
Maya communities have been shown to exhibit type 2 diabetes (T2D) with high prevalence compared with Mexican mestizo populations. Furthermore, some variants associated with the risk for T2D have been described. In this study, we describe the results of a pilot genome wide association study (GWAS) using 817,823 single nucleotide polymorphisms (SNPs) to identify candidate variants for replication in future studies. Herein, we present the GWAS study data, which were divided into three parts: first, 1289 ancestry informative markers (AIMs) were selected for Latino populations containing European, African, and Native American SNPs obtained from the literature; second, a GWAS hypothesis free to select candidate genes associated with T2D was performed, which identified 24 candidate genes; and third, 39 SNPs previously associated with T2D or related traits were replicated. This article is associated with the original article published in "Gene" under the title Pilot genome-wide association study identifying novel risk loci for type 2 diabetes in a Maya population".
与墨西哥混血人群相比，玛雅人群的2型糖尿病（T2D）患病率较高。此外，已经描述了一些与T2D风险相关的变异。在本研究中，我们描述了一项先导全基因组关联研究（GWAS）的结果，该研究使用817,823个单核苷酸多态性（SNP）来识别未来研究中用于复制的候选变异。在此，我们展示了GWAS研究数据，这些数据分为三个部分：第一，从文献中获取的包含欧洲、非洲和美洲原住民SNP的1289个祖先信息标记（AIM）被选用于拉丁裔人群；第二，进行了一项无GWAS假设的研究，以选择与T2D相关的候选基因，该研究确定了24个候选基因；第三，对先前与T2D或相关性状相关的39个SNP进行了复制。本文与发表在《基因》杂志上的题为“在玛雅人群中进行的先导全基因组关联研究，识别2型糖尿病的新风险位点”的原始文章相关。
