State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, Changchun 130012, P. R. China.
Analyst. 2020 Jan 20;145(2):313-320. doi: 10.1039/c9an01365b.
Lung cancer is one of the most common malignancies and the leading cause of cancer-related death worldwide. Among the technologies suitable for the rapid and accurate molecular diagnosis of lung cancer, ambient mass spectrometry (AMS) has gained increasing interest as it allows the direct profiling of molecular information from various biological samples (e.g., tissue, serum, urine and sputum) in real-time and with minimal or no sample pretreatment. This minireview summarizes the applications of AMS in lung cancer studies (including tissue molecular identification, the discovery of potential biomarkers, and surgical margin assessment), and discusses the challenges and perspectives of AMS in the clinical precision molecular diagnosis of lung cancer.
肺癌是最常见的恶性肿瘤之一，也是全球癌症相关死亡的主要原因。在适合快速准确进行肺癌分子诊断的技术中，环境质谱（AMS）越来越受到关注，因为它允许实时直接分析来自各种生物样本（例如组织、血清、尿液和痰液）的分子信息，而且几乎不需要或无需样品预处理。本综述总结了 AMS 在肺癌研究中的应用（包括组织分子鉴定、潜在生物标志物的发现以及手术切缘评估），并讨论了 AMS 在肺癌临床精准分子诊断中面临的挑战和前景。
