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Flavin-containing monooxygenases: new structures from old proteins.

作者信息

Phillips Ian R, Shephard Elizabeth A

机构信息

Department of Structural and Molecular Biology, University College London, London, UK.

School of Biological and Chemical Sciences, Queen Mary University of London, London, UK.

出版信息

Nat Struct Mol Biol. 2020 Jan;27(1):3-4. doi: 10.1038/s41594-019-0356-1.

DOI:10.1038/s41594-019-0356-1
PMID:31873301
Abstract
摘要

相似文献

1
Flavin-containing monooxygenases: new structures from old proteins.含黄素单加氧酶:源于旧有蛋白质的新结构
Nat Struct Mol Biol. 2020 Jan;27(1):3-4. doi: 10.1038/s41594-019-0356-1.
2
Flavin dependent monooxygenases.黄素依赖单加氧酶。
Arch Biochem Biophys. 2014 Feb 15;544:2-17. doi: 10.1016/j.abb.2013.12.005. Epub 2013 Dec 17.
3
Microbial Flavoprotein Monooxygenases as Mimics of Mammalian Flavin-Containing Monooxygenases for the Enantioselective Preparation of Drug Metabolites.微生物黄素蛋白单加氧酶作为哺乳动物含黄素单加氧酶的模拟物用于对映选择性制备药物代谢物
Drug Metab Dispos. 2016 Aug;44(8):1270-6. doi: 10.1124/dmd.115.069104. Epub 2016 Mar 16.
4
Oxaziridines as possible intermediates in flavin monooxygenases.氮杂环丙烷作为黄素单加氧酶中可能的中间体。
Proc Natl Acad Sci U S A. 1974 Jul;71(7):2646-50. doi: 10.1073/pnas.71.7.2646.
5
Formation of hydrogen peroxide and N-hydroxylated amines catalyzed by pulmonary flavin-containing monooxygenases in the presence of primary alkylamines.
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6
Tissue- and species-dependent expression of multiple forms of mammalian microsomal flavin-containing monooxygenase.哺乳动物微粒体含黄素单加氧酶多种形式的组织和物种依赖性表达。
Mol Pharmacol. 1987 Jun;31(6):569-74.
7
Potential role of the flavin-containing monooxygenases in the metabolism of endogenous compounds.含黄素单加氧酶在内源性化合物代谢中的潜在作用。
Chem Biol Interact. 1995 Apr 28;96(1):47-55. doi: 10.1016/0009-2797(94)03582-s.
8
The Origin and Evolution of Baeyer-Villiger Monooxygenases (BVMOs): An Ancestral Family of Flavin Monooxygenases.拜耳-维利格单加氧酶(BVMOs)的起源与进化:黄素单加氧酶的一个原始家族
PLoS One. 2015 Jul 10;10(7):e0132689. doi: 10.1371/journal.pone.0132689. eCollection 2015.
9
Bioactivation of xenobiotics by flavin-containing monooxygenases.含黄素单加氧酶对外源化合物的生物活化作用。
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Characterization of two human flavin-containing monooxygenase (form 3) enzymes expressed in Escherichia coli as maltose binding protein fusions.两种作为麦芽糖结合蛋白融合体在大肠杆菌中表达的人含黄素单加氧酶(3型)的特性分析。
Drug Metab Dispos. 1997 Aug;25(8):1001-7.

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Spontaneously hypertensive rats exhibit increased liver flavin monooxygenase expression and elevated plasma TMAO levels compared to normotensive and Ang II-dependent hypertensive rats.与正常血压大鼠和血管紧张素II依赖性高血压大鼠相比,自发性高血压大鼠的肝脏黄素单加氧酶表达增加,血浆氧化三甲胺水平升高。
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FMO family may serve as novel marker and potential therapeutic target for the peritoneal metastasis in gastric cancer.FMO家族可能作为胃癌腹膜转移的新型标志物和潜在治疗靶点。
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3

本文引用的文献

1
Revealing the moonlighting role of NADP in the structure of a flavin-containing monooxygenase.揭示NADP在含黄素单加氧酶结构中的兼职作用。
Proc Natl Acad Sci U S A. 2008 May 6;105(18):6572-7. doi: 10.1073/pnas.0800859105. Epub 2008 Apr 28.
2
Multisubstrate flavin-containing monooxygenases: applications of mechanism to specificity.
Chem Biol Interact. 1995 Apr 28;96(1):57-73. doi: 10.1016/0009-2797(94)03583-t.
Evolution of enzyme functionality in the flavin-containing monooxygenases.
黄素单加氧酶中酶功能的进化。
Nat Commun. 2023 Feb 24;14(1):1042. doi: 10.1038/s41467-023-36756-x.