Department of Clinical Nutrition, German Institute of Human Nutrition, Potsdam-Rehbruecke, 14558, Nuthetal, Germany; German Center for Diabetes Research (Deutsches Zentrum für Diabetesforschung e.V.), Ingolstädter Landstraße 1, 85764, Neuherberg, Germany; Department of Endocrinology, Diabetes and Nutrition, Campus Benjamin Franklin, Charité University Medicine, Hindenburgdamm 30, 12203, Berlin, Germany.
Department of Clinical Nutrition, German Institute of Human Nutrition, Potsdam-Rehbruecke, 14558, Nuthetal, Germany; German Center for Diabetes Research (Deutsches Zentrum für Diabetesforschung e.V.), Ingolstädter Landstraße 1, 85764, Neuherberg, Germany.
Peptides. 2020 Mar;125:170237. doi: 10.1016/j.peptides.2019.170237. Epub 2019 Dec 23.
The gastric inhibitory polypeptide receptor (GIPR) regulates postprandial metabolism. In this context GIPR SNP rs10423928 seems toplay an important role in modulating glucose metabolism and insulinsensitivity. However, evidence regarding thisparticular SNP is still vague. In this study, we collected baseline data from four different dietaryintervention studies. We genotyped 424 subjects with prediabetes and 73with diabetes for GIPR SNP rs10423928 and examined its impact on glucosemetabolism, insulin sensitivity and body fat accumulation. We extended previous data by showing that carriers of the A allele withprediabetes displayed increased fasting glucose (p = 0.015). Unexpectedly,A allele carriers showed lower glucose levels 2 h (p = 0.021) after anoral glucose challenge compared to T/T homozygous individuals. A allelecarriers also showed significantly higher insulin sensitivity (p < 0.001)(assessed by Cederholm Index), indicating an enhanced ß-cell response. This study points to a potential protective role for rs10423928 inglucose metabolism and insulin sensitivity in subjects with prediabetes.Further studies are necessary to confirm these results.
胃抑制多肽受体（GIPR）调节餐后代谢。在这种情况下，GIPR SNP rs10423928 似乎在调节葡萄糖代谢和胰岛素敏感性方面起着重要作用。然而，关于该特定 SNP 的证据仍然模糊不清。在这项研究中，我们从四项不同的饮食干预研究中收集了基线数据。我们对 424 名糖尿病前期患者和 73 名糖尿病患者进行了 GIPR SNP rs10423928 的基因分型，并检查了其对葡萄糖代谢、胰岛素敏感性和体脂积累的影响。我们通过显示糖尿病前期患者携带 A 等位基因的个体空腹血糖升高（p = 0.015），扩展了以前的数据。出乎意料的是，与 T/T 纯合子个体相比，A 等位基因携带者在口服葡萄糖负荷后 2 小时的血糖水平更低（p = 0.021）。A 等位基因携带者的胰岛素敏感性也显著更高（p < 0.001）（通过 Cederholm 指数评估），表明β细胞反应增强。这项研究表明，rs10423928 对糖尿病前期患者的葡萄糖代谢和胰岛素敏感性可能具有潜在的保护作用。需要进一步的研究来证实这些结果。
