Department of Dermatology, University of Rome Guglielmo Marconi, Rome, Italy.
Department of Dermatology, University Medical Center Mainz, Mainz, Germany.
Expert Rev Clin Pharmacol. 2020 Feb;13(2):157-161. doi: 10.1080/17512433.2020.1709825. Epub 2020 Jan 6.
: Pyoderma gangrenosum (PG) is a noninfectious, reactive inflammatory neutrophilic dermatosis that is commonly associated with autoimmune and neoplastic disorders. There are emerging diagnostic tools and treatment options for PG.: The diagnosis of PG should be seriously considered when managing ulcers to avoid unnecessary medical and surgical complications with prompt and suitable treatment. There are no standardized treatment guidelines for PG, and current therapy largely depends on the severity and progression of the disease. Systemic corticosteroids, immunosuppressant therapy, and biologic agents remain mainstay therapies. In this article, we present a literature review of recent diagnostic and novel treatment options for the management of PG. The literature research considered clinical studies or scientific reviews. Studies were identified by searching electronic databases and reference lists of respective articles till August 2019.: The true diagnosis of PG is challenging, as there is no diagnostic gold standard. PARACELSUS is a novel diagnostic tool. Biologics and small molecules are emerging systemic therapy options that are relatively new in treatment of PG.
: 坏疽性脓皮病（PG）是一种非传染性、反应性、中性粒细胞性炎症性皮肤病，常与自身免疫和肿瘤性疾病有关。目前有一些新兴的诊断工具和治疗选择可用于 PG。: 在处理溃疡时，应认真考虑 PG 的诊断，以避免不必要的医疗和手术并发症，并及时进行适当的治疗。目前还没有 PG 的标准化治疗指南，而且目前的治疗主要取决于疾病的严重程度和进展。全身皮质类固醇、免疫抑制剂治疗和生物制剂仍然是主要的治疗方法。在本文中，我们对 PG 的管理的最新诊断和新型治疗选择进行了文献回顾。文献研究考虑了临床研究或科学综述。通过搜索电子数据库和各自文章的参考文献列表，直到 2019 年 8 月，确定了研究。: PG 的真正诊断具有挑战性，因为目前还没有诊断的金标准。PARACELSUS 是一种新的诊断工具。生物制剂和小分子是新兴的系统治疗选择，在 PG 的治疗中相对较新。
