Sauerwein W, Feldmann H J
Strahlenklinik, Universität Essen.
Strahlenther Onkol. 1988 Oct;164(10):567-73.
From 1973 through 1986, twelve patients suffering from carcinomas of the outer auditory canal were irradiated at the Radiologic Hospital of Essen. The five-year survival was 64% after postoperative irradiation and 0% after irradiation alone. Considering the data communicated by other authors, the following therapy recommendations can be deduced: early stages where bones or cartilages are not involved represent an indication for sole operation. These tumors can be successfully treated by sole radiotherapy, too. In case of greater tumors, combined surgery and postoperative radiotherapy is the most favorable method. Besides a high total dose (50 to 60 Gy for microscopic tumor residues, about 70 Gy for macroscopic tumor residues), a sufficiently great target volume has to be chosen which includes the ear, the temporal bone, the preauricular lymph nodes and the angle of mandible. To prevent bone and cartilage necroses, it is recommended to restrict the individual doses to 1.8 to 2 Gy each.
1973年至1986年期间,埃森放射医院对12例外耳道癌患者进行了放射治疗。术后放疗的五年生存率为64%,单纯放疗的五年生存率为0%。综合其他作者公布的数据,可以得出以下治疗建议:早期未累及骨质或软骨的病例适合单纯手术治疗。这些肿瘤也可通过单纯放疗成功治疗。对于较大的肿瘤,手术联合术后放疗是最理想的治疗方法。除了高总剂量(显微镜下肿瘤残留为50至60 Gy,肉眼可见肿瘤残留约为70 Gy)外,还必须选择足够大的靶区,包括耳、颞骨、耳前淋巴结和下颌角。为防止骨和软骨坏死,建议将单次剂量限制在每次1.8至2 Gy。