Institute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti-inflammatory and Immune Medicine, Ministry of Education, Anhui Collaborative Innovation, China; Center of Anti-inflammatory and Immune Medicine, Hefei, 230032, Anhui Province, China.
Institute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti-inflammatory and Immune Medicine, Ministry of Education, Anhui Collaborative Innovation, China; Center of Anti-inflammatory and Immune Medicine, Hefei, 230032, Anhui Province, China.
Immunobiology. 2020 Mar;225(2):151881. doi: 10.1016/j.imbio.2019.11.016. Epub 2019 Nov 28.
If the body's immune system is disordered and begins to attack "self" and therefore, its own tissues this is considered to be an autoimmune pathology. The specific mechanisms vary between the different diseases and have not always been elucidated but chronic, non-resolving inflammation is a common theme in the pathogenesis of autoimmune diseases. Interestingly, it has been shown that development and occurrence of various inflammatory responses are closely correlated to endoplasmic reticulum stress. Therefore, this review discusses the current progress of research about the relationship between autoimmune diseases and endoplasmic reticulum stress, specifically the unfolded protein response (UPR).
如果人体的免疫系统紊乱并开始攻击“自身”，即自身组织，那么这被认为是一种自身免疫病理学。不同疾病的具体机制有所不同，尚未完全阐明，但慢性、非解决性炎症是自身免疫性疾病发病机制中的一个共同主题。有趣的是，已经表明各种炎症反应的发展和发生与内质网应激密切相关。因此，本综述讨论了自身免疫性疾病与内质网应激之间关系的研究进展，特别是未折叠蛋白反应 (UPR)。
