Chandra Harish, Gupta Arvind K, Nath Uttam K, Singh Neha, Kumar Utpal, Kishore Sanjeev
Department of Pathology and Lab Medicine, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.
Department of Medical Oncology and Hematology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.
J Family Med Prim Care. 2019 Dec 10;8(12):3944-3948. doi: 10.4103/jfmpc.jfmpc_539_19. eCollection 2019 Dec.
Pancytopenia, an important hematological presentation is associated with different causes, which may vary in different regions. Uttarakhand, a north Himalayan state of India lacks studies of pancytopenia and the prevalent causes present in this region. Therefore, the present study was conducted to study the clinico-hematological profile of pancytopenia in a tertiary care center in the Uttarakhand, a north Himalayan state of India. It was also intended to study if these causes showed any variation from other studies done in different regions of India.
The present observational study was conducted in a tertiary care institute situated in Uttarakhand state of India over a period of 1 year and 8 month from June 2017 to Feb 2019 including all the cases of pancytopenia.
The most common cause of pancytopenia was megaloblastic anemia (25%), followed by aleukemic leukemia and hypoplastic/aplastic anemia (19.1% each). Visceral leishmaniasis also constituted an important cause of pancytopenia in this study (11.7%).
The study concludes that megaloblastic anemia and aleukemic leukemia are the most common cause of pancytopenia. Although leishmaniasis is considered to be non-endemic in this region, it constitutes an important cause of pancytopenia here. The clinicians, especially the physicians practicing the primary care and pathologists, should be aware of the different causes of pancytopenia present in this Himalayan region of India; therefore, delay in diagnosis can be prevented along with unnecessary investigations.
全血细胞减少是一种重要的血液学表现，其病因各异，在不同地区可能有所不同。印度北喜马拉雅邦的北阿坎德邦缺乏关于全血细胞减少及其该地区常见病因的研究。因此，本研究旨在探讨印度北喜马拉雅邦北阿坎德邦一家三级医疗中心全血细胞减少的临床血液学特征。同时，本研究还旨在探讨这些病因与印度其他地区的研究结果是否存在差异。
本观察性研究于2017年6月至2019年2月在印度北阿坎德邦的一家三级医疗机构进行，为期1年零8个月，纳入所有全血细胞减少病例。
全血细胞减少最常见的病因是巨幼细胞贫血（25%），其次是白血病前期和再生障碍性贫血（各占19.1%）。内脏利什曼病也是本研究中全血细胞减少的一个重要病因（11.7%）。
本研究得出结论，巨幼细胞贫血和白血病前期是全血细胞减少最常见的病因。尽管利什曼病在该地区被认为是非地方性疾病，但它是该地区全血细胞减少的一个重要病因。临床医生，尤其是从事初级保健的医生和病理学家，应该了解印度这个喜马拉雅地区全血细胞减少的不同病因；因此，可以避免诊断延误以及不必要的检查。
