The Department of Geriatric Medicine, The University of Tokyo, Tokyo, Japan.
Division of Department of Respiratory Medicine, Jichi Medical University Saitama Medical Center, Saitama, Japan.
Sci Rep. 2019 Dec 27;9(1):20206. doi: 10.1038/s41598-019-56759-3.
Chronic obstructive pulmonary disease (COPD) often accompanies type 2 diabetes mellitus (T2DM). However, background factors affecting these diseases in the elderly remain unclear. Eligible patients with T2DM were divided into two age groups-non-elderly (<65 years) and elderly (≥65 years); COPD, ratio of forced expiratory volume in one second to forced expiratory volume (FEV1/FVC ratio), and percent predicted forced expiratory volume in one second (FEV1% predicted) were examined, and factors related to reduced respiratory function according to age group were evaluated. In total, 371 patients with T2DM were analysed. COPD was found in 9 patients (5.3%) in the non-elderly group and 45 (22.5%) in the elderly group. In the elderly, male sex, low body mass index (BMI), insulin therapy, and high C-peptide immunoreactivity levels were factors related to COPD. In the non-elderly, age, female sex, high BMI were factors related to decreased FEV1% predicted. Female sex was factor related to decreased FEV1% predicted in both age groups. Low BMI was a factor related to reduced respiratory function in elderly patients and high BMI was a factor related to reduced respiratory function in non-elderly patients. Thus, BMI needs to be managed according to the age and general condition of T2DM patients.
慢性阻塞性肺疾病（COPD）常伴有 2 型糖尿病（T2DM）。然而，影响老年人这些疾病的背景因素仍不清楚。将符合条件的 T2DM 患者分为两个年龄组-非老年组（<65 岁）和老年组（≥65 岁）；检查 COPD、一秒用力呼气量与用力肺活量的比值（FEV1/FVC 比值）和一秒用力呼气量预计值的百分比（FEV1%预计值），并评估根据年龄组与呼吸功能下降相关的因素。共分析了 371 例 T2DM 患者。非老年组有 9 例（5.3%）和老年组有 45 例（22.5%）患有 COPD。在老年组中，男性、低体重指数（BMI）、胰岛素治疗和高 C 肽免疫反应水平是与 COPD 相关的因素。在非老年组中，年龄、女性、高 BMI 是与 FEV1%预计值降低相关的因素。女性是两个年龄组中与 FEV1%预计值降低相关的因素。低 BMI 是老年患者呼吸功能下降的相关因素，高 BMI 是非老年患者呼吸功能下降的相关因素。因此，BMI 需要根据 T2DM 患者的年龄和一般情况进行管理。
