Taiyuan University of Technology, China.
Shanxi Medical University, Taiyuan, China.
J Atten Disord. 2021 Jul;25(9):1215-1229. doi: 10.1177/1087054719892887. Epub 2019 Dec 30.
Brain network studies have revealed abnormal topology asymmetry of white matter (WM) in ADHD. Recently, rich club organization was proposed to be a key feature of brain network topology. However, abnormalities in the rich club organization of hemispheric WM networks in ADHD remain unclear. Forty ADHD patients and 51 normal controls participated in this study. Structural networks were reconstructed based on diffusion tensor imaging (DTI) and analyzed with graph theory. The two groups exhibited different patterns of asymmetry in connectivity measures of rich club connections. ADHD patients showed more feeder connections than normal controls. Reduced rightward asymmetry was observed in connectivity measures of local connections involving several peripheral regions of the ADHD patients. In addition, abnormal regional asymmetry scores were associated with ADHD symptoms. The topological changes in rich club organization provide a novel insight into the alteration of WM connections in ADHD.
脑网络研究揭示了 ADHD 患者白质（WM）的拓扑异常不对称性。最近，丰富俱乐部组织被提出是脑网络拓扑的一个关键特征。然而，ADHD 患者半球 WM 网络丰富俱乐部组织的异常仍不清楚。40 名 ADHD 患者和 51 名正常对照者参与了这项研究。结构网络是基于弥散张量成像（DTI）重建的，并采用图论进行了分析。两组在丰富俱乐部连接的连通性测量的不对称性模式上表现出不同。ADHD 患者比正常对照组有更多的馈送连接。在涉及 ADHD 患者几个外周区域的局部连接的连通性测量中，观察到右向不对称性降低。此外，异常的区域不对称分数与 ADHD 症状有关。丰富俱乐部组织的拓扑变化为 WM 连接在 ADHD 中的改变提供了新的见解。
