School of Environment and Energy, South China University of Technology, Guangzhou 510006, PR China.
Guangzhou CAS Test Technical Services Co., Ltd, Guangzhou 510650, PR China.
J Hazard Mater. 2022 Aug 15;436:129142. doi: 10.1016/j.jhazmat.2022.129142. Epub 2022 May 13.
Identifying the attenuation characteristics of drugs in sewage and sewers is one of the important factors to improve the accuracy of wastewater-based epidemiology (WBE) application. In this study, 28 drugs including antidepressants, cardiovascular drugs, antihistamines, anticonvulsants and some of their human metabolites were chosen as the targets to study the hydrolysis, adsorption, and biodegradation at different temperatures in sewage and sewers. The interaction between drugs degradation and community structure of biofilm was also investigated. In the simulated sewers, the removal percentages of 12 parent or drug metabolites are 0-20%, such as demethylvenlafaxine, fluvoxamine, etc., which are highly stable chemicals and suitable to be chosen as biomarkers for WBE back-calculation under appropriate circumstances. Fourteen drugs including venlafaxine and citalopram have removal percentages of 20-60%. While paroxetine and sertraline, with removal percentage of 100%, are the most unstable and cannot be used as biomarkers. Among the 28 drugs, there are 25 drugs that have a higher loss rate in the aerobic sewer than that in the anaerobic sewer in this study. During drug exposure in anaerobic biofilms, species abundance first decreased and then increased. Species abundance and diversity in aerobic biofilm generally showed a decreasing trend. In addition, Proteobacteria and Spirochaetota were the dominant phyla in both sewers.
鉴定污水和污水管道中药物的衰减特性是提高基于污水的流行病学（WBE）应用准确性的重要因素之一。在这项研究中，选择了 28 种药物，包括抗抑郁药、心血管药物、抗组胺药、抗惊厥药及其一些人体代谢物，作为目标，研究了不同温度下污水和污水管道中的水解、吸附和生物降解作用。还研究了药物降解与生物膜群落结构之间的相互作用。在模拟污水管道中，12 种母体药物或药物代谢物的去除率为 0-20%，如去甲文拉法辛、氟伏沙明等，这些都是高度稳定的化学物质，在适当的情况下可以作为 WBE 反向计算的生物标志物。包括文拉法辛和西酞普兰在内的 14 种药物的去除率为 20-60%。而帕罗西汀和舍曲林的去除率为 100%，是最不稳定的，不能用作生物标志物。在这 28 种药物中，有 25 种在本研究中好氧污水管中的损失率高于厌氧污水管。在厌氧生物膜中暴露于药物时，物种丰度先减少后增加。好氧生物膜中的物种丰度和多样性通常呈下降趋势。此外，在两个污水管中，变形菌门和螺旋体门都是优势门。
