Selezneva N D
Zh Nevropatol Psikhiatr Im S S Korsakova. 1988;88(6):93-100.
The relation of progressive course of Alzheimer's disease with the age of its onset was established by a retrospective analysis of the psychopathological structure and initial signs of the disease. The overall duration of the disease decreased as the age of its onset increased. This was mainly due to a reduced duration of the initial stage and to a lesser extent to shortening the pronounced dementia stage. Aphasia and apraxia showed different characteristics and rate of occurrence at the initial phase of the ailment. Early initial appearance of motor disorders was characteristic of the disease started before 60. In these cases the distinct cortical functions could be deteriorated in a relatively independent manner. Three major clinical types of the initial stage of the disease are described which correlated with its progression rate and the onset age.
通过对阿尔茨海默病的精神病理结构和初始症状进行回顾性分析，确定了该疾病进展过程与其发病年龄之间的关系。随着发病年龄的增加，疾病的总体持续时间缩短。这主要是由于初始阶段的持续时间缩短，在较小程度上是由于明显痴呆阶段的缩短。失语症和失用症在疾病初期表现出不同的特征和发生率。运动障碍早期出现是60岁前发病的该疾病的特征。在这些情况下，不同的皮质功能可能以相对独立的方式恶化。描述了该疾病初始阶段的三种主要临床类型，它们与其进展速度和发病年龄相关。
