Gavrilova S I, Voskresenskaia N I, Trubnikov V I
Zh Nevropatol Psikhiatr Im S S Korsakova. 1990;90(9):38-43.
Twenty-one cases of familial hereditary Alzheimer's disease and 17 sporadic cases were under observation. The probands' clinical status was assessed during a number of years in accordance with the standard method (based on a unified map). The clinical parameters (dementia structure, intensity of neurologic disorders, and so forth) were correlated at the identical disease stages. The differences in the character of the initial disease manifestations and the tempo of its progression as well as definite differences in the dementia structure at the pronounced stage and in the final stage allowed a conclusion about the ++clinico-genetic heterogeneity of the hereditary and sporadic cases of Alzheimer's disease.
观察了21例家族遗传性阿尔茨海默病患者和17例散发性病例。多年来，按照标准方法（基于统一图谱）对先证者的临床状况进行了评估。在相同的疾病阶段对临床参数（痴呆结构、神经功能障碍强度等）进行了相关性分析。初始疾病表现特征及其进展速度的差异，以及明显阶段和终末阶段痴呆结构的明确差异，使得能够得出关于阿尔茨海默病遗传性和散发性病例临床遗传异质性的结论。
