Division of Cardiovascular Surgery, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Yonsei University Health System, Seoul, Korea.
Division of Cardiovascular Surgery, CHA University Bundang Medical Center, Seongnam, Korea.
Yonsei Med J. 2020 Jan;61(1):40-47. doi: 10.3349/ymj.2020.61.1.40.
The long-term outcomes of aortic wrapping in patients with ascending aortic aneurysms, which are rare, but can be fatal, remain poorly understood. This retrospective study analyzed the outcomes of aortic diameter, including aortic root, ascending aorta, and proximal arch diameters, after aortic wrapping during aortic valve replacement surgery.
Ninety-six patients with ascending aortic dilation of 40-55 mm who underwent aortic wrapping during aortic valve replacement were selected for this study. Aortic diameter was measured at three levels perioperatively and at follow-up (median time of 9.1±4.2 years). A linear mixed-effects model was used to analyze aortic diameter expansion.
Freedom from adverse aortic events (aortic dissection or rupture, reoperation, or sudden death) at 10 years was 97.9%. No significant dilation at the level of the sinuses of Valsalva (0.069 mm/year, =0.524) or ascending aorta (0.152 mm/year, =0.124) was observed. Significant dilation occurred at the proximal aortic arch (0.343 mm/year, =0.006). Subgroup analysis with a multivariable linear mixed model identified initial ascending aortic diameter to be a significant predictor of proximal arch dilation (=0.032). Receiver operating characteristic curve analysis revealed that the cut-off for the prediction of proximal arch redilation was an initial mid-ascending aortic diameter of 47.0 mm (area under the curve 0.747, 90% confidence interval 0.613-0.881, =0.023).
Aortic wrapping could be considered as a safe and long-term therapeutic option. Redilation of the proximal arch should be carefully observed during long-term follow-up.
升主动脉瘤患者行主动脉包裹术的长期结果罕见,但可能致命,目前仍知之甚少。本回顾性研究分析了主动脉瓣置换术中行主动脉包裹术后主动脉直径(包括主动脉根部、升主动脉和近端弓直径)的变化。
选择 96 例升主动脉扩张至 40-55mm 的患者,在主动脉瓣置换术中行主动脉包裹术。在术前和术后(中位随访时间为 9.1±4.2 年)测量主动脉直径。采用线性混合效应模型分析主动脉直径扩张。
10 年无不良主动脉事件(主动脉夹层或破裂、再次手术或猝死)发生率为 97.9%。窦部(0.069mm/年,=0.524)或升主动脉(0.152mm/年,=0.124)无明显扩张。近端主动脉弓有明显扩张(0.343mm/年,=0.006)。多变量线性混合模型的亚组分析表明,初始升主动脉直径是近端弓扩张的显著预测因子(=0.032)。受试者工作特征曲线分析显示,预测近端弓再扩张的切点为初始升主动脉中段直径 47.0mm(曲线下面积 0.747,90%置信区间 0.613-0.881,=0.023)。
主动脉包裹术可作为一种安全且长期的治疗选择。在长期随访中应仔细观察近端弓的扩张。