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[结外NK/T细胞淋巴瘤免疫治疗的进展]

[Advances in immunotherapy of extranodal NK/T cell lymphoma].

作者信息

Hao D Q, Li L Q, Li M C, Gong L L

机构信息

Shandong First Medical University (Shandong Academy of Medical Sciences), Taian 271000, China.

Liaocheng People's Hospital, Otorhinolaryngology Head and Neck Surgery, Liaocheng 252000, China.

出版信息

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2019 Dec 7;54(12):949-953. doi: 10.3760/cma.j.issn.1673-0860.2019.12.015.

Abstract

Extranodal NK/T-cell lymphoma (ENKTCL) is a relatively rare group of highly aggressive non-Hodgkin's lymphoma (NHL). The disease has rapid clinical progress, high degree of malignancy and poor prognosis. Traditional chemoradiotherapy regimens have not shown good efficacy. In recent years, the immunotherapy of tumors has developed rapidly. At present, it has shown strong therapeutic activity in the treatment of various solid tumors such as non-small cell lung cancer, prostate cancer, melanoma and kidney cancer. Multiple tumor immunotherapy drugs have been approved by the US Food and Drug Administration (FDA) for clinical use. This article reviews recent novel immunotherapeutic regimens of ENKTCL, hoping to change the treatment modality of this malignant disease.

摘要

结外NK/T细胞淋巴瘤(ENKTCL)是一组相对罕见的高度侵袭性非霍奇金淋巴瘤(NHL)。该疾病临床进展迅速,恶性程度高,预后差。传统的放化疗方案疗效不佳。近年来,肿瘤免疫治疗发展迅速。目前,它在治疗非小细胞肺癌、前列腺癌、黑色素瘤和肾癌等各种实体瘤方面已显示出强大的治疗活性。多种肿瘤免疫治疗药物已获美国食品药品监督管理局(FDA)批准用于临床。本文综述了ENKTCL近期的新型免疫治疗方案,希望能改变这种恶性疾病的治疗模式。

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