[抗惊厥制剂苯佐那在人体中的代谢]
[Metabolism of the anticonvulsant preparation Benzonal in the human body].
作者信息
Okudzhava V M, Chankvetadze B G, Rogava M M, Rukhadze M D
出版信息
Zh Nevropatol Psikhiatr Im S S Korsakova. 1988;88(7):94-5.
PMID:3188784
Abstract
One of the metabolites of the anticonvulsant drug Benzonal (BZL) has been isolated and its chemical structure studied. High-performance liquid chromatography (HPLC) was utilized for isolation of the metabolite from the blood plasma in patients after a single oral BZL dose of 100 mg. Using this technique and ultraviolet, infrared and mass spectrometries BZL was found to be partially metabolized into phenobarbital by human organism.
摘要
抗惊厥药物苯唑那（BZL）的一种代谢产物已被分离出来，并对其化学结构进行了研究。在单次口服100毫克BZL的患者血浆中，采用高效液相色谱法（HPLC）分离该代谢产物。利用该技术以及紫外、红外和质谱分析法发现，人体可将BZL部分代谢为苯巴比妥。
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