State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China.
State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China.
Carbohydr Polym. 2020 Feb 15;230:115650. doi: 10.1016/j.carbpol.2019.115650. Epub 2019 Nov 20.
Chondroitin sulfate (CS) is a naturally derived bioactive macromolecule and the major component of extracellular matrix (ECM), which widely distributed in various organisms and has attracted much attention due to their significant bioactivities. It is regarded as a favorable biomaterial that has been applied extensively in field of drug delivery and tissue engineering due to its property of non-poisonous, biodegradation, biocompatible and as a major component of ECM. The present article reviews the structure and bioactivities of CS, from the preparation to structure analysis, and emphatically focuses on the biomaterial exertion in delivery system and tissue engineering. At the same time, the present application status and prospect of CS are analyzed and the biomaterial exertion of CS in delivery system and various tissue engineering are also comparatively discussed in view of biomaterial development.
硫酸软骨素（CS）是一种天然存在的生物活性大分子，也是细胞外基质（ECM）的主要成分，广泛分布于各种生物体中，由于其显著的生物活性而备受关注。由于其无毒、可生物降解、生物相容性以及作为 ECM 的主要成分等特性，它被认为是一种很有前途的生物材料，已经广泛应用于药物输送和组织工程领域。本文综述了 CS 的结构和生物活性，从其制备到结构分析，重点介绍了其在输送系统和组织工程中的生物材料应用。同时，还分析了 CS 的现状和前景，并从生物材料发展的角度，比较了 CS 在输送系统和各种组织工程中的生物材料应用。
