Department of Pharmaceutics, Centre for Pharmaceutical Nanotechnology, National Institute of Pharmaceutical Education & Research (NIPER), Sector 67, S.A.S. Nagar (Mohali), Punjab 160062, India.
Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, Telangana, India.
Carbohydr Polym. 2022 Jun 15;286:119305. doi: 10.1016/j.carbpol.2022.119305. Epub 2022 Mar 3.
Chondroitin Sulfate (CS) is an anionic hetero polysaccharide possessing anti-inflammatory, antioxidant, antitumor, anticoagulant and antithrombogenic activities. It is biodegradable and biocompatible in nature. Further, it inherits the ability of active and subcellular targeting due to its affinity for CD 44 receptors and glycosylation enzymes, which are overexpressed on the surface of tumor cells and intracellular organelles respectively. CS is known to degrade in presence of physiological stimuli, the hyaluronidase (HAase) enzyme and reactive oxygen species (ROS), assisting in site specific drug release. Due to these properties, it serve as a promising biomaterial for drug delivery and tissue engineering. In this review, the fundamental theory of CS, CS-based nanocarriers for the delivery of biopharmaceuticals and stimuli sensitive delivery systems such as HAase and ROS responsive nanocarriers for tumor targeted delivery are discussed critically. In addition, the manuscript describes the application of CS-based tissue constructs in tissue engineering and wound healing.
硫酸软骨素（CS）是一种带负电荷的杂多糖，具有抗炎、抗氧化、抗肿瘤、抗凝和抗血栓形成的作用。它在性质上是可生物降解和生物相容的。此外，由于其对 CD44 受体和糖基化酶的亲和力，CS 具有主动和亚细胞靶向的能力，而 CD44 受体和糖基化酶分别在肿瘤细胞表面和细胞内细胞器上过度表达。CS 在存在生理刺激物、透明质酸酶（HAase）酶和活性氧（ROS）的情况下会降解，有助于实现特定部位的药物释放。由于这些特性，CS 是一种很有前途的药物输送和组织工程生物材料。在这篇综述中，我们批判性地讨论了 CS 的基本理论、基于 CS 的用于生物制药传递的纳米载体以及刺激响应性传递系统，如针对肿瘤的 HAase 和 ROS 响应性纳米载体。此外，本文还描述了基于 CS 的组织构建体在组织工程和伤口愈合中的应用。
