老年人对硝西泮的敏感性增加。
Increased sensitivity to nitrazepam in old age.
作者信息
Castleden C M, George C F, Marcer D, Hallett C
出版信息
Br Med J. 1977 Jan 1;1(6052):10-2. doi: 10.1136/bmj.1.6052.10.
Abstract
The effects of a single 10 mg oral dose of nitrazepam were compared with those of a placebo in healthy young and old people. Both the young and the elderly slept better on three successive nights after nitrazepam but they felt less awake at 12 and 36 hours (P less than 0-01). Elderly people made significantly more mistakes in a psychomotor test than did the young, despite similar plasma concentrations of nitrazepam and half lives in the two groups. This difference in response to psychomotor testing is probably explained by an increased sensitivity of the ageing brain to the action of nitrazepam.
摘要
在健康的年轻人和老年人中，比较了口服10毫克硝西泮单次剂量与安慰剂的效果。年轻人和老年人在服用硝西泮后的连续三个晚上睡眠质量都有所改善，但在12小时和36小时时他们感觉清醒程度降低（P小于0.01）。尽管两组硝西泮的血浆浓度和半衰期相似，但老年人在一项精神运动测试中犯的错误明显多于年轻人。对精神运动测试的这种反应差异可能是由于衰老的大脑对硝西泮作用的敏感性增加所致。
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2
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3
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