Gorbunova O, Chernysheva E
Federal state budgetary educational institution of higher education "Astrakhan State Medical University" of the Ministry of health of the Russian Federation, Astrakhan, Russia.
Georgian Med News. 2019 Nov(296):75-81.
To illuminate modern ideas about Gilbert's syndrome (GS). GS is a common familial hyperbilirubinemia that can reduce the risk of various age-related diseases due to the antioxidant properties of bilirubin. In this case, slightly elevated unconjugated bilirubin in GS is strongly associated with a "reduced" prevalence of chronic diseases, in particular cardiovascular disease (CVD), as well as CVD-related and all-cause mortality. These reports challenge the dogma that bilirubin is simply a potentially neurotoxic byproduct of heme catabolism, and emphasize the importance of understanding its potential beneficial physiological and harmful pathophysiological effects. With this information, we hope to improve understanding of bilirubin metabolic disorders, highlight the diagnostic importance of these conditions, and map out the potential impact of GS on disease resistance.
为阐明有关吉尔伯特综合征（GS）的现代观点。GS是一种常见的家族性高胆红素血症，由于胆红素的抗氧化特性，它可以降低各种与年龄相关疾病的风险。在这种情况下，GS中未结合胆红素的轻度升高与慢性病，特别是心血管疾病（CVD）以及与CVD相关的全因死亡率的“降低”患病率密切相关。这些报告挑战了胆红素仅仅是血红素分解代谢潜在神经毒性副产物的教条，并强调了理解其潜在有益生理作用和有害病理生理作用的重要性。有了这些信息，我们希望增进对胆红素代谢紊乱的理解，突出这些病症的诊断重要性，并勾勒出GS对疾病抵抗力的潜在影响。
