Research Department of Primary Care and Population Health, Institute of Epidemiology and Health Care, University College London, London, UK.
J Gastroenterol Hepatol. 2013 Oct;28(10):1643-7. doi: 10.1111/jgh.12279.
Gilbert's syndrome is a common familial hyperbilirubinemia that may reduce the risk of various age-related diseases because of the antioxidant properties of bilirubin. We conducted a large cohort study using The Health Improvement Network primary care database and compared all-cause mortality rates in those with and without Gilbert's syndrome.
Mortality rates in patients with a diagnosis of Gilbert's syndrome and raised bilirubin level (n = 4266) were compared with those of patients with similar characteristics but with normal bilirubin levels (n = 21 968). Multivariate Poisson regression was also used to estimate adjusted mortality rate ratios.
During the 350 000 PYs of follow up across the Gilbert's and comparison cohorts, there were 1174 deaths. Mortality rates were 24/10 000 PYs in the Gilbert's cohort versus 50/10 000 PYs in the comparison cohort. Mortality rates were around half in patients with Gilbert's syndrome after accounting for sociodemographics and general health indicators (adjusted mortality rate ratio: 0.5 [95% confidence interval; 0.4-0.7; P < 0.001]).
Mortality rates observed for people with Gilbert's syndrome in the general population are almost half those of people without evidence of Gilbert's syndrome.
吉尔伯特综合征是一种常见的家族性高胆红素血症，由于胆红素具有抗氧化特性，可能会降低各种与年龄相关疾病的风险。我们利用英国国家卫生服务初级保健数据库开展了一项大型队列研究，比较了患有和不患有吉尔伯特综合征患者的全因死亡率。
将诊断为吉尔伯特综合征且胆红素升高（n=4266）患者的死亡率与具有相似特征但胆红素水平正常（n=21968）患者的死亡率进行比较。同时还使用多变量泊松回归估计了校正后的死亡率比值。
在吉尔伯特和对照组队列的 35 万患者年随访期间，共有 1174 人死亡。在吉尔伯特组，死亡率为 24/10000 患者年，而对照组为 50/10000 患者年。在考虑了社会人口统计学和一般健康指标后，患有吉尔伯特综合征患者的死亡率接近对照组的一半（校正死亡率比值：0.5 [95%置信区间；0.4-0.7；P<0.001]）。
在普通人群中，患有吉尔伯特综合征患者的死亡率几乎是无吉尔伯特综合征患者的一半。
