Smiley Abbas, King David, Harezlak Jaroslaw, Dinh Paul, Bidulescu Aurelian
Department of Epidemiology and Biostatistics, School of Public Health, Indiana University, 1025 E 7th St., Bloomington, IN 47405 USA.
J Diabetes Metab Disord. 2019 Jun 22;18(2):315-322. doi: 10.1007/s40200-019-00415-0. eCollection 2019 Dec.
In the current literature, the association between sleep and different lipids is inconsistent. We aimed to assess the association of sleep with HDL cholesterol, triglyceride, and LDL cholesterol in the National Health and Nutrition Examination Survey (NHANES), 2013/2014.
We included 2705 participants from NHANES, 2013/2014. Cross-sectional information was measured on sleep duration and HDL cholesterol/triglyceride/LDL cholesterol. Generalized additive models (GAM) were constructed to assess the smooth relationship between the HDL cholesterol/triglyceride/LDL cholesterol, and the sleep duration. Models were adjusted for age, sex, race, marital status, household size, sitting time and physical activity. Effective degree of freedom (EDF) value in GAM indicated the amount of non-linearity of the smooth. EDF = 1 was indicative of a linear pattern of association. A value greater than 1 denoted a more complex association between outcome and sleep duration.
The highest mean HDL cholesterol level was observed in participants sleeping 8 h/day. There was a significant non-linear association between sleep duration and HDL cholesterol in unadjusted GAM (EDF = 2.58, = 0.002) and adjusted GAM (EDF = 1.85, = 0.003). The lowest mean triglyceride level was observed in people sleeping 6 h/day. There was a significant non-linear association between sleep duration and triglyceride in unadjusted GAM (EDF = 3.05, = 0.02) and adjusted GAM (EDF = 1.78, P = 0.02). There was no significant non-linear association between sleep duration and LDL cholesterol in either unadjusted GAM (EDF = 1.01, = 0.2) or adjusted GAM (EDF = 1.01, = 0.8).
Short sleep duration was associated with low HDL cholesterol/high triglyceride. Further longitudinal studies are warranted to shed extra light on this relationship.
在当前文献中，睡眠与不同脂质之间的关联并不一致。我们旨在评估2013/2014年美国国家健康与营养检查调查（NHANES）中睡眠与高密度脂蛋白胆固醇、甘油三酯和低密度脂蛋白胆固醇之间的关联。
我们纳入了2013/2014年NHANES的2705名参与者。测量了睡眠时长和高密度脂蛋白胆固醇/甘油三酯/低密度脂蛋白胆固醇的横断面信息。构建广义相加模型（GAM）以评估高密度脂蛋白胆固醇/甘油三酯/低密度脂蛋白胆固醇与睡眠时长之间的平滑关系。模型对年龄、性别、种族、婚姻状况、家庭规模、久坐时间和身体活动进行了调整。GAM中的有效自由度（EDF）值表明平滑的非线性程度。EDF = 1表示线性关联模式。大于1的值表示结局与睡眠时长之间存在更复杂的关联。
每天睡眠8小时的参与者中观察到最高的平均高密度脂蛋白胆固醇水平。在未调整的GAM（EDF = 2.58，P = 0.002）和调整后的GAM（EDF = 1.85，P = 0.003）中，睡眠时长与高密度脂蛋白胆固醇之间存在显著的非线性关联。每天睡眠6小时的人群中观察到最低的平均甘油三酯水平。在未调整的GAM（EDF = 3.05，P = 0.02）和调整后的GAM（EDF = 1.78，P = 0.02）中，睡眠时长与甘油三酯之间存在显著的非线性关联。在未调整的GAM（EDF = 1.01，P = 0.2）或调整后的GAM（EDF = 1.01，P = 0.8）中，睡眠时长与低密度脂蛋白胆固醇之间均无显著的非线性关联。
短睡眠时长与低高密度脂蛋白胆固醇/高甘油三酯有关。有必要进行进一步的纵向研究以更深入地了解这种关系。
