中国东部人群中自我报告的睡眠时间与血清脂质异常的相关性：一项基于人群的横断面调查。

Associations between self-reported sleep duration and abnormal serum lipids in eastern China: a population-based cross-sectional survey.

机构信息

Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China.

Department of Noncommunicable Disease Prevention, Nanjing Municipal Center for Disease Control and Prevention, Nanjing, China.

出版信息

Sleep Med. 2022 Jul;95:1-8. doi: 10.1016/j.sleep.2022.04.004. Epub 2022 Apr 16.

DOI:10.1016/j.sleep.2022.04.004

PMID:35533627

Abstract

OBJECTIVE

To evaluate the associations between sleep duration and total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C).

METHODS

The present study included 60,283 adults aged ≥18 years from the Chronic Disease and Risk Factor Surveillance in Nanjing. Generalized additive model (GAM) with forward stepwise selection method was used to analyze the nonlinear relationships between sleep duration and abnormal serum lipids. The reported effective degree of freedom (EDF) values in GAM indicates the degree of smooth curvature. EDF = 1 is a sign of linear correlation between predictors and outcome. EDF >1 is the sign of a more complex relationship between sleep duration and abnormal serum lipids.

RESULTS

The evaluation of interaction of sex and sleep duration by using multivariable GAM revealed a U-shaped correlation between sleep duration and dyslipidemia (EDF = 4.60, P < 0.001), high TC (EDF = 3.38, P < 0.001), and high LDL-C (EDF = 3.67, P < 0.001) in male, and a U-shaped correlation between sleep duration and dyslipidemia (EDF = 4.69, P < 0.001), high TC (EDF = 3.33, P < 0.001), and high LDL-C (EDF = 3.21, P < 0.001) in female. There was a U-shaped correlation between sleep duration and high TG in male (EDF = 3.84, P < 0.001) and semi-linear correlation in female (EDF = 1.82, P = 0.028). Moreover, there was a linear correlation between sleep duration and low HDL-C in men (EDF = 1.04, P = 0.002), but no significant correlation in women (EDF = 3.18, P = 0.080).

CONCLUSIONS

Both shorter and longer sleep durations were associated with abnormal serum lipid profiles in men and women.

摘要

目的

评估睡眠时间与总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）和低密度脂蛋白胆固醇（LDL-C）之间的关系。

方法

本研究纳入了来自南京市慢性病与危险因素监测的 60283 名年龄≥18 岁的成年人。采用逐步正向选择法的广义加性模型（GAM）分析睡眠时间与异常血清脂质之间的非线性关系。GAM 中报告的有效自由度（EDF）值表示预测因子与结果之间的平滑曲率程度。EDF=1 表示预测因子与结果之间存在线性关系。EDF>1 表示睡眠时间与异常血清脂质之间的关系更复杂。

结果

通过多变量 GAM 评估性别与睡眠时间之间的相互作用，结果显示男性中睡眠时间与血脂异常（EDF=4.60，P<0.001）、高 TC（EDF=3.38，P<0.001）和高 LDL-C（EDF=3.67，P<0.001）之间呈 U 型相关，女性中睡眠时间与血脂异常（EDF=4.69，P<0.001）、高 TC（EDF=3.33，P<0.001）和高 LDL-C（EDF=3.21，P<0.001）之间呈 U 型相关。男性中睡眠时间与高 TG 之间呈 U 型相关（EDF=3.84，P<0.001），女性中呈半线性相关（EDF=1.82，P=0.028）。此外，男性睡眠时间与低 HDL-C 之间呈线性相关（EDF=1.04，P=0.002），而女性无显著相关性（EDF=3.18，P=0.080）。