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瘢痕疙瘩和增生性瘢痕的诊断与治疗——2018年日本瘢痕研讨会共识文件

Diagnosis and Treatment of Keloids and Hypertrophic Scars-Japan Scar Workshop Consensus Document 2018.

作者信息

Ogawa Rei, Akita Sadanori, Akaishi Satoshi, Aramaki-Hattori Noriko, Dohi Teruyuki, Hayashi Toshihiko, Kishi Kazuo, Kono Taro, Matsumura Hajime, Muneuchi Gan, Murao Naoki, Nagao Munetomo, Okabe Keisuke, Shimizu Fumiaki, Tosa Mamiko, Tosa Yasuyoshi, Yamawaki Satoko, Ansai Shinichi, Inazu Norihisa, Kamo Toshiko, Kazki Reiko, Kuribayashi Shigehiko

机构信息

1Department of Plastic, Reconstructive and Aesthetic Surgery, Nippon Medical School, 1-1-5 Sendagi Bunkyo-ku, Tokyo, 113-8603 Japan.

2Department of Plastic Surgery, Wound Repair and Regeneration, Fukuoka University, Fukuoka, 814-0180 Japan.

出版信息

Burns Trauma. 2019 Dec 27;7:39. doi: 10.1186/s41038-019-0175-y. eCollection 2019.

DOI:10.1186/s41038-019-0175-y
PMID:31890718
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6933735/
Abstract

There has been a long-standing need for guidelines on the diagnosis and treatment of keloids and hypertrophic scars that are based on an understanding of the pathomechanisms that underlie these skin fibrotic diseases. This is particularly true for clinicians who deal with Asian and African patients because these ethnicities are highly prone to these diseases. By contrast, Caucasians are less likely to develop keloids and hypertrophic scars, and if they do, the scars tend not to be severe. This ethnic disparity also means that countries vary in terms of their differential diagnostic algorithms. The lack of clear treatment guidelines also means that primary care physicians are currently applying a hotchpotch of treatments, with uneven outcomes. To overcome these issues, the Japan Scar Workshop (JSW) has created a tool that allows clinicians to objectively diagnose and distinguish between keloids, hypertrophic scars, and mature scars. This tool is called the JSW Scar Scale (JSS) and it involves scoring the risk factors of the individual patients and the affected areas. The tool is simple and easy to use. As a result, even physicians who are not accustomed to keloids and hypertrophic scars can easily diagnose them and judge their severity. The JSW has also established a committee that, in cooperation with outside experts in various fields, has prepared a Consensus Document on keloid and hypertrophic scar treatment guidelines. These guidelines are simple and will allow even inexperienced clinicians to choose the most appropriate treatment strategy. The Consensus Document is provided in this article. It describes (1) the diagnostic algorithm for pathological scars and how to differentiate them from clinically similar benign and malignant tumors, (2) the general treatment algorithms for keloids and hypertrophic scars at different medical facilities, (3) the rationale behind each treatment for keloids and hypertrophic scars, and (4) the body site-specific treatment protocols for these scars. We believe that this Consensus Document will be helpful for physicians from all over the world who treat keloids and hypertrophic scars.

摘要

长期以来,一直需要基于对这些皮肤纤维化疾病潜在病理机制的理解而制定的瘢痕疙瘩和增生性瘢痕的诊断与治疗指南。对于处理亚洲和非洲患者的临床医生来说尤其如此,因为这些种族极易患上这些疾病。相比之下,白种人患瘢痕疙瘩和增生性瘢痕的可能性较小,而且即便患病,瘢痕往往也不严重。这种种族差异还意味着不同国家在鉴别诊断算法方面存在差异。缺乏明确的治疗指南也意味着基层医疗医生目前采用的治疗方法五花八门,效果参差不齐。为克服这些问题,日本瘢痕研讨会(JSW)创建了一种工具,使临床医生能够客观地诊断并区分瘢痕疙瘩、增生性瘢痕和成熟瘢痕。这种工具称为JSW瘢痕量表(JSS),它涉及对个体患者和受影响区域的风险因素进行评分。该工具简单易用。因此,即使是不熟悉瘢痕疙瘩和增生性瘢痕的医生也能轻松诊断并判断其严重程度。JSW还成立了一个委员会,该委员会与各领域的外部专家合作,编写了一份关于瘢痕疙瘩和增生性瘢痕治疗指南的共识文件。这些指南很简单,即使是经验不足的临床医生也能据此选择最合适的治疗策略。本文提供了这份共识文件。它描述了(1)病理性瘢痕的诊断算法以及如何将其与临床相似的良性和恶性肿瘤区分开来,(2)不同医疗机构对瘢痕疙瘩和增生性瘢痕的一般治疗算法,(3)瘢痕疙瘩和增生性瘢痕每种治疗方法背后的原理,以及(4)这些瘢痕的特定身体部位治疗方案。我们相信这份共识文件将对世界各地治疗瘢痕疙瘩和增生性瘢痕的医生有所帮助。

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Clin Pract. 2025 Jul 14;15(7):131. doi: 10.3390/clinpract15070131.
4
Autologous Skin Cell Suspension Monotherapy Without Split-Thickness Skin Grafting for Deep Dermal Burns in Pediatric Patients: A Case Series.小儿深度真皮烧伤自体皮肤细胞悬液单药治疗且不进行分层皮片移植:病例系列
Cureus. 2025 Apr 29;17(4):e83210. doi: 10.7759/cureus.83210. eCollection 2025 Apr.
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An individualized strategy of dynamic therapy using non-ablative fractional laser combined with intralesional triamcinolone injection for pediatric hypertrophic burn scars.一种使用非剥脱性分次激光联合病灶内注射曲安奈德治疗小儿增生性烧伤瘢痕的个体化动态治疗策略。
Lasers Med Sci. 2025 Apr 21;40(1):203. doi: 10.1007/s10103-025-04452-5.
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Manual Fractional Technology with CO Laser Combined with Transdermal Drug Delivery for Hypertrophic Scar: A Retrospective Study.CO2激光手动分次技术联合经皮给药治疗增生性瘢痕:一项回顾性研究
Aesthetic Plast Surg. 2025 Apr 2. doi: 10.1007/s00266-025-04837-5.
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Deciphering Pain and Pruritus in Keloids from the Perspective of Neurological Dysfunction: Where Are We Now?从神经功能障碍角度解读瘢痕疙瘩中的疼痛与瘙痒:我们目前的进展如何?
Biomedicines. 2025 Mar 8;13(3):663. doi: 10.3390/biomedicines13030663.
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Fractional erbium-doped yttrium aluminum garnet laser-assisted drug delivery: impact of triamcinolone acetonide formulation on drug permeation.分数掺铒钇铝石榴石激光辅助药物递送:曲安奈德制剂对药物渗透的影响。
Drug Deliv Transl Res. 2024 Dec 24. doi: 10.1007/s13346-024-01771-y.
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Finite Element Analysis of the Stress Changes Associated With the Growth of Acne Keloids.痤疮瘢痕疙瘩生长相关应力变化的有限元分析
Plast Reconstr Surg Glob Open. 2024 Dec 20;12(12):e6365. doi: 10.1097/GOX.0000000000006365. eCollection 2024 Dec.
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[Effectiveness of stepwise progressive ultra-tension-reducing suture method in treatment of high-tension wounds on chest, back, and limbs].[逐步渐进式减张缝合方法治疗胸背部及四肢高压创面的疗效]
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2024 Dec 15;38(12):1505-1509. doi: 10.7507/1002-1892.202409048.
病灶内切除联合病灶内局部冷冻疗法可改善小儿瘢痕疙瘩的治疗效果。
Ann R Coll Surg Engl. 2017 Nov;99(8):e233-e335. doi: 10.1308/rcsann.2017.0156. Epub 2017 Sep 15.
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A Case of Keloids Complicated by Castleman's Disease: Interleukin-6 as a Keloid Risk Factor.1例瘢痕疙瘩合并卡斯特曼病:白细胞介素-6作为瘢痕疙瘩的危险因素
Plast Reconstr Surg Glob Open. 2017 May 16;5(5):e1336. doi: 10.1097/GOX.0000000000001336. eCollection 2017 May.
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Combined effects of long-pulsed neodymium-yttrium-aluminum-garnet laser, diprospan and 5-fluorouracil in the treatment of keloid scars.长脉冲钕钇铝石榴石激光、得宝松和5-氟尿嘧啶联合治疗瘢痕疙瘩的效果
Exp Ther Med. 2017 Jun;13(6):3607-3612. doi: 10.3892/etm.2017.4438. Epub 2017 May 8.
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Keloid and Hypertrophic Scars Are the Result of Chronic Inflammation in the Reticular Dermis.瘢痕疙瘩和增生性瘢痕是网状真皮层慢性炎症的结果。
Int J Mol Sci. 2017 Mar 10;18(3):606. doi: 10.3390/ijms18030606.
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Triamcinolone emboli leading to central retinal artery occlusion: a multimodal imaging study.曲安奈德栓子导致视网膜中央动脉阻塞:一项多模态影像学研究。
BMJ Case Rep. 2017 Feb 22;2017:bcr2016218908. doi: 10.1136/bcr-2016-218908.
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Evidence of invasive and noninvasive treatment modalities for hypertrophic scars: A systematic review.肥厚性瘢痕的侵入性和非侵入性治疗方式的证据:一项系统综述。
Wound Repair Regen. 2017 Jan;25(1):139-144. doi: 10.1111/wrr.12507. Epub 2017 Jan 31.
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Autologous fat grafting does not improve burn scar appearance: A prospective, randomized, double-blinded, placebo-controlled, pilot study.自体脂肪移植不能改善烧伤瘢痕外观:一项前瞻性、随机、双盲、安慰剂对照的试点研究。
Burns. 2017 May;43(3):486-489. doi: 10.1016/j.burns.2016.09.019. Epub 2016 Dec 29.
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Reconstruction after Anterior Chest Wall Keloid Resection Using Internal Mammary Artery Perforator Propeller Flaps.使用胸廓内动脉穿支螺旋桨皮瓣修复前胸壁瘢痕疙瘩切除术后缺损
Plast Reconstr Surg Glob Open. 2016 Sep 29;4(9):e1049. doi: 10.1097/GOX.0000000000001049. eCollection 2016 Sep.