Adebayo Adeniyi A, Oboh Ganiyu, Ademosun Ayokunle O
Functional Foods and Nutraceutical Research Unit, Department of Biochemistry, Federal University of Technology, P.M.B. 704, Akure, 340001, Nigeria.
Heliyon. 2019 Dec 18;5(12):e03035. doi: 10.1016/j.heliyon.2019.e03035. eCollection 2019 Dec.
Hyperglycemia, an important feature of diabetes, can cause oxidative stress, which is associated with varieties of diabetic complications including erectile dysfunction. Therefore, this study sought to investigate the effect of almond-supplemented diet on some biochemical indices relevant to erection in diabetic male rats. Forty-two male rats were divided into two groups: A (n = 6) and B (n = 36). Diabetes was induced in Group B via injection of a single dose of STZ (50 mg/kg) intraperitoneally and confirmed 72 h after induction. Diabetic rats (blood glucose ≥250 mg/dL) were subsequently divided into six groups (n = 6). Fourteen days after confirmation of diabetes, rats were fed with diets containing almond drupe and seeds (10 and 20% inclusion) for fourteen days. The effects of the diets on blood glucose, sexual behavior, sexual hormones, phosphodiesterase-5 activity, nitric oxide, HS, and AGEs levels were evaluated. Significant increase in blood glucose level, phosphodiesterase-5 activity, and glycated hemoglobin was observed in diabetic rats. Furthermore, diabetes caused a significant decrease in nitric oxide, HS, sexual hormones (testosterone, follicle-stimulating hormone and luteinizing hormone) levels, and sexual behavioral indices. However, treatment with diets supplemented with almond drupe and seeds significantly reversed these effects in diabetic rats. Findings in this study revealed that almond-supplemented diets enhance some important biomarkers relevant to erection in diabetic rats. Thus, dietary inclusion of almond (drupe and seeds) could serve as a cheap and readily available nutraceutical in the management of erectile dysfunction associated with diabetes.
高血糖是糖尿病的一个重要特征，可导致氧化应激，而氧化应激与包括勃起功能障碍在内的多种糖尿病并发症相关。因此，本研究旨在探讨补充杏仁饮食对糖尿病雄性大鼠一些与勃起相关的生化指标的影响。42只雄性大鼠分为两组：A组（n = 6）和B组（n = 36）。通过腹腔注射单剂量链脲佐菌素（STZ，50 mg/kg）诱导B组大鼠患糖尿病，并在诱导后72小时进行确认。随后将糖尿病大鼠（血糖≥250 mg/dL）分为六组（n = 6）。糖尿病确诊14天后，给大鼠喂食含杏仁核和杏仁籽（添加量分别为10%和20%）的饲料，持续14天。评估这些饲料对血糖、性行为、性激素、磷酸二酯酶-5活性、一氧化氮、透明质酸和晚期糖基化终末产物水平的影响。观察到糖尿病大鼠的血糖水平、磷酸二酯酶-5活性和糖化血红蛋白显著升高。此外，糖尿病导致一氧化氮、透明质酸、性激素（睾酮、促卵泡激素和黄体生成素）水平以及性行为指标显著下降。然而，用添加杏仁核和杏仁籽的饲料进行治疗可显著逆转糖尿病大鼠的这些影响。本研究结果表明，补充杏仁的饮食可增强糖尿病大鼠一些与勃起相关的重要生物标志物。因此，在饮食中添加杏仁（核和籽）可作为一种廉价且易于获得的营养保健品，用于管理与糖尿病相关的勃起功能障碍。
