Hathout Rania M
Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Ain Shams University, Cairo 11566, Egypt.
ACS Omega. 2019 Dec 16;4(26):21909-21913. doi: 10.1021/acsomega.9b02895. eCollection 2019 Dec 24.
Glaucoma is a very serious disease that can lead to blindness in severe cases. In an attempt to increase the efficacy of the drugs used in treating this disease, many particulate systems (micro/nano and lipid-based/nonlipid-based) have been exploited. In this study, the meta-analysis approach was implemented in order to explore the published studies and extract the literature-based evidence (proof-of-concept studies = 16) that the particulate systems increase the efficiency of the investigated intraocular pressure drugs as demonstrated by the increase in the area under effect curve. Comparison of micron particles versus nanoparticles on the one hand and lipid-based versus nonlipid-based on the other hand, as subgroups of the meta-analysis, was also included in the study where the latter comparison led to insignificant differences, whereas the former has proven the superiority of the nanoparticles over the micronized counterparts.
青光眼是一种非常严重的疾病，在严重情况下可导致失明。为了提高用于治疗这种疾病的药物的疗效，人们开发了许多微粒系统（基于微/纳米以及基于脂质/非脂质）。在本研究中，采用了荟萃分析方法来探究已发表的研究，并提取基于文献的证据（概念验证研究 = 16 项），即微粒系统可提高所研究的眼内压药物的效率，这一点通过效应曲线下面积的增加得以证明。作为荟萃分析的子组，还对一方面的微米颗粒与纳米颗粒以及另一方面的基于脂质与基于非脂质进行了比较，该研究中后一种比较结果无显著差异，而前一种比较已证明纳米颗粒优于微粉化对应物。
