Shan Peiwei, Zhuo Chuanjun, Ma Xiaoyan, Sang Hong, Zhong Baoliang, Lin Xiaodong, Ji Feng, Chen Min, Tian Hongjun, Zhao Yanling, Pan Jianshe
Labortorary of Psychiatric-Neuroimaging-Genetics Laboratory (PNG-Lab), Wenzhou Seventh People's Hospital, Wenzhou, Zhejiang Province, China.
Department of Psychiatry, School of Mental Health, Jining Medical University, Jining, Shandong Province, China.
J Int Med Res. 2020 Apr;48(4):300060519875830. doi: 10.1177/0300060519875830. Epub 2019 Dec 31.
This study was performed to investigate the effects and associated global functional connectivity density (gFCD) alterations associated with the use of atypical antipsychotics in healthy individuals with auditory verbal hallucinations (Hi-AVHs) using gFCD mapping techniques.
A magnetic resonance imaging database of 38 Hi-AVHs with chronic or severe AVH symptoms was generated. The Hi-AVHs were administered an atypical antipsychotic (risperidone) for 24 weeks and monitored for a treatment response. All patients underwent functional magnetic resonance imaging pre- and post-treatment.
gFCD alterations were found in the auditory-memory-language and visual circuit regions pre- and post-treatment. However, gFCD alterations differed between patients with strong and weak treatment responses.
This is the first report to show that atypical antipsychotics can improve the symptoms of AVHs and that the treatment effects are associated with gFCD alterations in the auditory-memory-language circuit. These findings provide a foundation for future exploration of new treatment strategies for Hi-AVHs.
本研究旨在使用全局功能连接密度（gFCD）映射技术，调查非典型抗精神病药物对患有幻听的健康个体（Hi-AVHs）的影响以及相关的gFCD改变。
建立了一个包含38名有慢性或严重幻听症状的Hi-AVHs的磁共振成像数据库。给Hi-AVHs服用非典型抗精神病药物（利培酮）24周，并监测治疗反应。所有患者在治疗前和治疗后均接受功能磁共振成像检查。
治疗前后在听觉-记忆-语言和视觉回路区域发现了gFCD改变。然而，治疗反应强和弱的患者之间gFCD改变有所不同。
这是第一份表明非典型抗精神病药物可改善幻听症状且治疗效果与听觉-记忆-语言回路中的gFCD改变相关的报告。这些发现为未来探索Hi-AVHs的新治疗策略奠定了基础。
