School of Mental Health, Jining Medical University, Jining, 272119, Shandong Province, China.
Psychiatric-Neuroimaging-Genetics Laboratory, Wenzhou Seventh People's Hospital, Wenzhou, 325000, Zhejiang Province, China.
Brain Imaging Behav. 2020 Dec;14(6):2553-2558. doi: 10.1007/s11682-019-00207-3.
Few studies have reported on brain functional differences between healthy individuals with auditory verbal hallucinations (Hi-AVH) with and without insight, so we designed a study to address this knowledge gap. We enrolled 12 Hi-AVH with insight, 15 Hi-AVH without insight, and 15 AVH-free controls (Healthy controls). Global functional connectivity density (gFCD) mapping was used to estimate brain networks. We found that the most common alterations in both Hi-AVH groups were increased gFCD in superior parietal lobule and superior temporal gyrus. We also found that distinct brain functional patterns of Hi-AVH without insight comprised lower gFCD in the frontal lobe oculomotor area, dorsolateral prefrontal cortex, supramarginal gyrus, primary auditory cortex, sensorimotor cortex, ventral anterior, and posterior cingulate Our pilot findings support the hypothesis that abnormal reciprocal action in the circuits for processing perception, memory, language, and attentional control may be pathological features of auditory verbal hallucinations.
很少有研究报道有听觉言语幻觉（Hi-AVH）的健康个体中，有自知力和无自知力者之间的大脑功能差异，因此我们设计了一项研究来填补这一知识空白。我们招募了 12 名有自知力的 Hi-AVH 患者、15 名无自知力的 Hi-AVH 患者和 15 名无听觉言语幻觉的健康对照者（健康对照组）。我们使用全脑功能连接密度（gFCD）映射来估计脑网络。我们发现，在这两组 Hi-AVH 患者中，最常见的改变是顶叶上回和颞上回的 gFCD 增加。我们还发现，无自知力的 Hi-AVH 患者存在明显的不同脑功能模式，包括眶额运动区、背外侧前额叶皮质、缘上回、初级听觉皮层、感觉运动皮层、腹前扣带和后扣带回的额叶 gFCD 降低。我们的初步研究结果支持这样一种假设，即处理感知、记忆、语言和注意力控制的回路中异常的相互作用可能是听觉言语幻觉的病理特征。
