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A phase III study comparing the clinical utility of four regimens of 5-fluorouracil: a preliminary report.

作者信息

Ansfield F, Klotz J, Nealon T, Ramirez G, Minton J, Hill G, Wilson W, Davis H, Cornell G

出版信息

Cancer. 1977 Jan;39(1):34-40. doi: 10.1002/1097-0142(197701)39:1<34::aid-cncr2820390107>3.0.co;2-2.

DOI:10.1002/1097-0142(197701)39:1<34::aid-cncr2820390107>3.0.co;2-2
PMID:318916
Abstract

A clinical trial involving 462 colon, rectum, and breast cancer patients randomized among four different dosage regimens of 5-FU (an intravenous loading course, a weekly intravenous schedule, a nontoxic schedule, and an oral schedule) has shown a significantly better response among colon-rectum cancer patients for the intravenous loading course. In addition, duration of response and time to progression are also significantly better. Overall survival is approaching significance for the colon rectum group (p value .082). In contrast, breast cancer patients show little difference between treatments. Toxicity is somewhat higher for the loading course.

摘要

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1
A phase III study comparing the clinical utility of four regimens of 5-fluorouracil: a preliminary report.
Cancer. 1977 Jan;39(1):34-40. doi: 10.1002/1097-0142(197701)39:1<34::aid-cncr2820390107>3.0.co;2-2.
2
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Chemotherapy of advanced measurable colon and rectal carcinoma with oral 5-fluorouracil, alone or in combination with cyclophosphamide or 6-thioguanine, with intravenous 5-fluorouracil or beta-2'-deoxythioguanosine or with oral 3(4-methyl-cyclohexyl)-1(2-chlorethyl)-1-nitrosourea: a Phase II-III study of the Eastern Cooperative Oncology Group (EST 4273).东部肿瘤协作组（EST 4273）的一项II-III期研究：口服5-氟尿嘧啶单药或联合环磷酰胺或6-硫鸟嘌呤、静脉注射5-氟尿嘧啶或β-2'-脱氧硫鸟苷或口服3(4-甲基环己基)-1(2-氯乙基)-1-亚硝基脲用于晚期可测量结肠癌和直肠癌的化疗
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Final results of a randomised phase III study on adjuvant chemotherapy with 5 FU and levamisol in colon and rectum cancer stage II and III by the Norwegian Gastrointestinal Cancer Group.挪威胃肠癌研究组关于5-氟尿嘧啶和左旋咪唑辅助化疗用于II期和III期结肠癌和直肠癌的随机III期研究的最终结果
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Comparison of oral ftorafur and intravenous 5-fluorouracil in patients with advanced cancer of the stomach, colon or rectum.口服替加氟与静脉注射5-氟尿嘧啶治疗晚期胃癌、结肠癌或直肠癌患者的比较。
Oncology. 1986;43(4):212-5. doi: 10.1159/000226367.

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